A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients

IF 33.2 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

The Innovation Pub Date : 2024-03-02 DOI:10.1016/j.xinn.2024.100603

Zhe Zhang, Wenjing Yang, Zhengshan Chen, Haoang Chi, Shipo Wu, Wanru Zheng, Ruochun Jin, Busen Wang, Yudong Wang, Nan Huo, Jinlong Zhang, Xiaohong Song, Liyang Xu, Jun Zhang, Lihua Hou, Wei Chen

引用次数: 0

Abstract

The vaccine-induced innate immune response is essential for the generation of an antibody response. To date, how Ad5-vectored vaccines are influenced by preexisting anti-Ad5 antibodies during activation of the early immune response remains unclear. Here, we investigated the specific alterations in GP-specific IgG-related elements of the early immune response at the genetic, molecular, and cellular levels on days 0, 1, 3, and 7 after Ad5-EBOV vaccination. In a causal multiomics analysis, distinct early immune responses associated with GP-specific IgG were observed in Ad5-EBOV recipients with a low level of preexisting anti-Ad5 antibodies. This study revealed the correlates of the Ad5-EBOV-induced IgG response and provided mechanistic evidence for overcoming preexisting Ad5 immunity during the administration of Ad5-vectored vaccines.

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一项因果多组学研究可分辨 Ad5 接种埃博拉疫苗受者的早期免疫特征

疫苗诱导的先天性免疫反应对抗体反应的产生至关重要。迄今为止，Ad5 接种的疫苗在激活早期免疫反应的过程中如何受到先前存在的抗 Ad5 抗体的影响仍不清楚。在这里，我们研究了接种 Ad5-EBOV 疫苗后第 0、1、3 和 7 天，早期免疫反应中 GP 特异性 IgG 相关元素在基因、分子和细胞水平上的具体改变。在一项因果多组学分析中，在预先存在低水平抗Ad5抗体的Ad5-EBOV受体中观察到了与GP特异性IgG相关的独特早期免疫反应。这项研究揭示了Ad5-EBOV诱导的IgG反应的相关性，并为在接种Ad5载体疫苗期间克服已有的Ad5免疫提供了机理证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The Innovation MULTIDISCIPLINARY SCIENCES-

CiteScore

38.30

自引率

1.20%

发文量

134

审稿时长

6 weeks

期刊介绍： The Innovation is an interdisciplinary journal that aims to promote scientific application. It publishes cutting-edge research and high-quality reviews in various scientific disciplines, including physics, chemistry, materials, nanotechnology, biology, translational medicine, geoscience, and engineering. The journal adheres to the peer review and publishing standards of Cell Press journals. The Innovation is committed to serving scientists and the public. It aims to publish significant advances promptly and provides a transparent exchange platform. The journal also strives to efficiently promote the translation from scientific discovery to technological achievements and rapidly disseminate scientific findings worldwide. Indexed in the following databases, The Innovation has visibility in Scopus, Directory of Open Access Journals (DOAJ), Web of Science, Emerging Sources Citation Index (ESCI), PubMed Central, Compendex (previously Ei index), INSPEC, and CABI A&I.