Integration of melt electrowritten microfibers with magnetoelastic sensors for continuous monitoring of cell growth†

IF 3.5 Q2 CHEMISTRY, ANALYTICAL
William S. Skinner, Paula G. Saiz, Ander Reizabal, Jeffrey E. Plumley, Paul D. Dalton and Keat Ghee Ong
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引用次数: 0

Abstract

Magnetoelastic sensors, which are wirelessly activated and interrogated via magnetic fields, have gained popularity for monitoring physical parameters such as mass loading and stress. The functionalization of the sensor surface has facilitated the development of biosensing devices with the capacity to monitor chemical/biological quantities such as liquid pH, bacteria, and cell growth in biological environments. In this study, melt electrowriting (MEW) is used for the first time to integrate user-defined microstructures onto the surface of magnetoelastic sensors, aiming to enhance their cell growth monitoring performance. Specifically, MEW is used to define specific topographies on the sensor surface, which enable custom control of attachment, distribution, and alignment of cells along the sensor surface. This technique holds potential for engineering tissues with predefined physical structures, as well as for the development of advanced monitoring systems for tracking the growth of adherent cells in real-time.

Abstract Image

将熔融电泳微纤维与磁弹性传感器集成在一起,用于连续监测细胞生长
磁弹性传感器可通过磁场进行无线激活和询问,在监测质量负荷和应力等物理参数方面颇受欢迎。传感器表面的功能化促进了生物传感设备的发展,使其能够监测生物环境中的化学/生物数量,如液体 pH 值、细菌和细胞生长。在这项研究中,首次使用熔融电写(MEW)将用户定义的微结构集成到磁弹性传感器表面,旨在提高其细胞生长监测性能。具体来说,MEW 用于在传感器表面定义特定的形貌,从而实现对细胞沿传感器表面的附着、分布和排列的定制控制。这项技术有望用于具有预定义物理结构的组织工程,以及用于开发实时跟踪附着细胞生长的先进监测系统。
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CiteScore
2.30
自引率
0.00%
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