Alcohol consumption questionnaire: Scale development in a sample of Mexican American young adults and association with ADH7

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol Pub Date : 2024-03-11 DOI:10.1016/j.alcohol.2024.03.006

{"title":"Alcohol consumption questionnaire: Scale development in a sample of Mexican American young adults and association with ADH7","authors":"","doi":"10.1016/j.alcohol.2024.03.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>To understand why some individuals who develop alcohol use disorders (AUD) first begin to drink heavily, a number of scales have been developed that index aspects of alcohol craving and restraint from drinking. We developed a new measure called the Alcohol Consumption Questionnaire (ACQ), based in part on items modified from scales used to index binge eating, because there are data to suggest that binge eating and binge drinking may share common antecedents. We present an initial validity study using data from a sample of Mexican Americans.</p></div><div><h3>Methods</h3><p>Data were from 699 Mexican American young adults in San Diego County, CA. A subsample (n = 60) had short-term test-retest data. Factor analysis and reliability assessment guided item reduction. Item response theory (IRT) analyses quantified item severity and identified questions with differential item functioning (DIF). Logistic regression assessed associations of mean scale scores with AUD, adjusting for key demographics, alcohol expectancies and subjective response to alcohol. We also examined associations with a protective genetic variant downstream from the alcohol dehydrogenase 7 (ADH7) gene.</p></div><div><h3>Results</h3><p>The scale was reduced from 20 to 14 questions, which can be summarized by a single overall score (Cronbach's alpha = 0.896) or by two sub-scores (Consumption: 12 items, Cronbach's alpha = 0.896; Enjoyment: 2 items, Cronbach's alpha = 0.780). Test-retest reliability was very high (0.80–0.98) in this sample. The overall ACQ score and each subdomain score were strongly associated with AUD (ORs = 5.95 mild; 11.41 moderate; 48.56 severe) and family history of AUD. Respondents with the protective genetic variant had significantly lower overall ACQ scores (p < 0.001).</p></div><div><h3>Conclusion</h3><p>The ACQ is a novel measure of alcohol consumption with strong relationships with both the AUD phenotype and ADH7 gene variants in a sample of Mexican American young adults.</p></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alcohol","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0741832924000491","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

To understand why some individuals who develop alcohol use disorders (AUD) first begin to drink heavily, a number of scales have been developed that index aspects of alcohol craving and restraint from drinking. We developed a new measure called the Alcohol Consumption Questionnaire (ACQ), based in part on items modified from scales used to index binge eating, because there are data to suggest that binge eating and binge drinking may share common antecedents. We present an initial validity study using data from a sample of Mexican Americans.

Methods

Data were from 699 Mexican American young adults in San Diego County, CA. A subsample (n = 60) had short-term test-retest data. Factor analysis and reliability assessment guided item reduction. Item response theory (IRT) analyses quantified item severity and identified questions with differential item functioning (DIF). Logistic regression assessed associations of mean scale scores with AUD, adjusting for key demographics, alcohol expectancies and subjective response to alcohol. We also examined associations with a protective genetic variant downstream from the alcohol dehydrogenase 7 (ADH7) gene.

Results

The scale was reduced from 20 to 14 questions, which can be summarized by a single overall score (Cronbach's alpha = 0.896) or by two sub-scores (Consumption: 12 items, Cronbach's alpha = 0.896; Enjoyment: 2 items, Cronbach's alpha = 0.780). Test-retest reliability was very high (0.80–0.98) in this sample. The overall ACQ score and each subdomain score were strongly associated with AUD (ORs = 5.95 mild; 11.41 moderate; 48.56 severe) and family history of AUD. Respondents with the protective genetic variant had significantly lower overall ACQ scores (p < 0.001).

Conclusion

The ACQ is a novel measure of alcohol consumption with strong relationships with both the AUD phenotype and ADH7 gene variants in a sample of Mexican American young adults.

Abstract Image

查看原文本刊更多论文

酒精消耗量问卷：墨西哥裔美国年轻人样本的量表开发及与 ADH7 的关联。

背景：为了了解为什么一些罹患酒精使用障碍（AUD）的人首先开始大量饮酒，已经开发了许多量表来反映对酒精的渴望和对饮酒的克制。我们开发了一种名为 "酒精消耗量问卷"（ACQ）的新量表，其部分依据是对暴饮暴食量表中的项目进行的修改，因为有数据表明，暴饮暴食和暴饮暴食可能有共同的前因后果。我们利用墨西哥裔美国人的样本数据进行了初步的有效性研究：数据来自加利福尼亚州圣地亚哥县的 699 名墨西哥裔美国年轻人。一个子样本（n=60）有短期测试-重测数据。在因子分析和信度评估的指导下减少了项目。项目反应理论（IRT）分析量化了项目的严重程度，并确定了具有差异项目功能（DIF）的问题。逻辑回归评估了量表平均得分与 AUD 的关联，并对主要人口统计学特征、酒精预期和对酒精的主观反应进行了调整。我们还研究了与酒精脱氢酶 7 基因（ADH7）下游保护性遗传变异的关系：结果：量表从 20 个问题减少到 14 个问题，可以用一个总分（Cronbach's alpha=0.896）或两个分值（消费：12 个项目，Cronbach's alpha=0.896）来概括：消费：12 个项目，Cronbach's alpha=0.896；享受：2 个项目，Cronbach's alpha=0.780）。该样本的重测信度非常高（0.80-0.98）。ACQ 总分和每个子域得分与 AUD（ORs= 5.95 轻度；11.41 中度；48.56 重度）和 AUD 家族史密切相关。具有保护性基因变异的受访者的 ACQ 总分明显较低（p 结论：ACQ 是一种新型的心理健康测试方法，可用于评估心理健康问题：ACQ 是一种新的酒精消费测量方法，在墨西哥裔美国年轻人样本中与 AUD 表型和 ADH7 基因变异都有密切关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Alcohol 医学-毒理学

CiteScore

4.60

自引率

4.30%

发文量

审稿时长

15.6 weeks

期刊介绍： Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects. Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.