Dissolution of presumed calcareous corneal degeneration with 13.8% ethylenediaminetetraacetic acid solution in 17 dogs.

IF 1.7 4区农林科学 Q2 VETERINARY SCIENCES

Veterinary ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-03-11 DOI:10.1111/vop.13207

Richard A Pytak, Neal T Wasserman

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引用次数: 0

Abstract

Purpose: To describe a novel treatment for dissolving calcareous corneal degeneration (CCD)-associated mineral in 17 dogs with 13.8% ethylenediaminetetraacetic acid (EDTA) solution.

Methods: Cases seen between 2021 and 2023 were reviewed. Seventeen dogs with CCD associated with corneal ulcerations were treated with a mineral dissolution procedure using 13.8% EDTA solution. A diamond burr keratotomy (DBK) was subsequently performed in some cases when residual mineralization remained present.

Results: Of the 19 eyes (17 dogs) included in the study, 10 eyes (8 dogs) required a DBK procedure. One eye (one dog) required a repeat procedure 26 weeks following the initial procedure and two eyes (one dog) required a repeat procedure 24 and 37 weeks following initial treatment in the left and right eye, respectively. Mean follow-up time to last recheck for eyes not requiring a second chelation procedure was 20.4 weeks (range, 10-47 weeks). At the last follow-up examination for all 17 dogs, the CCD resolved in 26.3%, improved in 57.9%, and recurred in 15.8% of eyes. Complications occurred in two eyes (two dogs) and included an infected stromal ulcer at 2-week recheck and the creation of a 40% depth stromal defect immediately following debridement. Both complications were successfully addressed with medical management.

Conclusions: The utilization of 13.8% EDTA solution appears to be an effective and safe means of treating lesions associated with CCD.

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用 13.8% 乙二胺四乙酸溶液溶解 17 只狗的假定钙化性角膜变性。

目的：描述用 13.8% 乙二胺四乙酸（EDTA）溶液溶解 17 只狗的钙化性角膜变性（CCD）相关矿物质的新型疗法：回顾 2021 年至 2023 年期间的病例。使用 13.8% 的乙二胺四乙酸（EDTA）溶液对 17 只患有伴有角膜溃疡的 CCD 的狗进行了矿物质溶解治疗。随后，在一些仍有残留矿化物的病例中进行了金刚石毛刺角膜切开术（DBK）：在参与研究的 19 只眼睛（17 只狗）中，有 10 只眼睛（8 只狗）需要进行 DBK 手术。一只眼睛（一只狗）需要在初次手术后 26 周再次进行手术，两只眼睛（一只狗）需要在初次治疗后 24 周再次进行手术，左眼和右眼需要在初次治疗后 37 周再次进行手术。不需要进行第二次螯合治疗的眼睛最后一次复查的平均随访时间为 20.4 周（范围为 10-47 周）。在对所有 17 只犬进行的最后一次随访检查中，26.3% 的犬只的 CCD 病情得到缓解，57.9% 的犬只病情得到改善，15.8% 的犬只病情复发。两只眼睛（两只狗）出现了并发症，包括两周复查时出现感染性基质溃疡，以及清创后立即出现深度为 40% 的基质缺损。这两种并发症均通过药物治疗成功解决：结论：使用 13.8% EDTA 溶液治疗与 CCD 相关的病变似乎是一种有效而安全的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary ophthalmology 农林科学-兽医学

CiteScore

2.70

自引率

37.50%

发文量

审稿时长

12-24 weeks

期刊介绍： Veterinary Ophthalmology is a peer-reviewed, international journal that welcomes submission of manuscripts directed towards academic researchers of veterinary ophthalmology, specialists and general practitioners with a strong ophthalmology interest. Articles include those relating to all aspects of: Clinical and investigational veterinary and comparative ophthalmology; Prospective and retrospective studies or reviews of naturally occurring ocular disease in veterinary species; Experimental models of both animal and human ocular disease in veterinary species; Anatomic studies of the animal eye; Physiological studies of the animal eye; Pharmacological studies of the animal eye.