Efficacy of transcranial photobiomodulation in the treatment for major depressive disorder: A TMS-EEG and pilot study.

IF 2.5 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine Pub Date : 2024-03-01 DOI:10.1111/phpp.12957

Wensi Hao, Xiaona Dai, Min Wei, Siran Li, Mao Peng, Qing Xue, Hua Lin, Huicong Wang, Penghui Song, Yuping Wang

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Abstract

Background: Major depressive disorder (MDD) was a prevalent mental condition that may be accompanied by decreased excitability of left frontal pole (FP) and abnormal brain connections. An 820 nm tPBM can induce an increase in stimulated cortical excitability. The purpose of our study was to establish how clinical symptoms and time-varying brain network connectivity of MDD were affected by transcranial photobiomodulation (tPBM).

Methods: A total of 11 patients with MDD received 820 nm tPBM targeting the left FP for 14 consecutive days. The severity of symptoms was evaluated by neuropsychological assessments at baseline, after treatment, 4-week and 8-week follow-up; 8-min transcranial magnetic stimulation combined electroencephalography (TMS-EEG) was performed for five healthy controls and five patients with MDD before and after treatment, and time-varying EEG network was analyzed using the adaptive-directed transfer function.

Results: All of scales scores in the 11 patients decreased significantly after 14-day tPBM (p < .01) and remained at 8-week follow-up. The time-varying brain network analysis suggested that the brain regions with enhanced connection information outflow in MDD became gradually more similar to healthy controls after treatment.

Conclusions: This study showed that tPBM of the left FP could improve symptoms of patients with MDD and normalize the abnormal network connections.

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经颅光生物调制治疗重度抑郁症的疗效：TMS-EEG和试验研究。

背景：重度抑郁症（MDD）是一种常见的精神疾病，可能伴有左额叶兴奋性降低和大脑连接异常。820 nm tPBM 可诱导刺激皮层兴奋性的增加。我们的研究旨在确定经颅光生物调控（tPBM）如何影响 MDD 的临床症状和时变脑网络连接：方法：共有11名多发性硬化症患者连续14天接受了以左侧FP为靶点的820纳米经颅光生物调控（tPBM）治疗。在基线、治疗后、4周和8周的随访中，通过神经心理学评估评估了症状的严重程度；在治疗前后，对5名健康对照组和5名MDD患者进行了8分钟经颅磁刺激联合脑电图（TMS-EEG）检查，并使用自适应定向传递函数分析了时变脑电网络：结果：经过 14 天的 tPBM 治疗后，11 名患者的所有量表评分均明显降低（p 结论：tPBM 对多发性硬化症患者的疗效显著：本研究表明，左侧 FP 的 tPBM 可以改善 MDD 患者的症状，并使异常网络连接正常化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodermatology, photoimmunology & photomedicine 医学-皮肤病学

CiteScore

4.40

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials. Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.

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