Modulators targeting protein-protein interactions in Mycobacterium tuberculosis

IF 6.9 1区生物学 Q1 MICROBIOLOGY

Microbiological research Pub Date : 2024-03-07 DOI:10.1016/j.micres.2024.127675

Guofeng Luo , Tianqi Ming , Luchuan Yang , Lei He , Tao Tao , Yanmei Wang

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引用次数: 0

Abstract

Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis), mainly transmitted through droplets to infect the lungs, and seriously affecting patients' health and quality of life. Clinically, anti-TB drugs often entail side effects and lack efficacy against resistant strains. Thus, the exploration and development of novel targeted anti-TB medications are imperative. Currently, protein-protein interactions (PPIs) offer novel avenues for anti-TB drug development, and the study of targeted modulators of PPIs in M. tuberculosis has become a prominent research focus. Furthermore, a comprehensive PPI network has been constructed using computational methods and bioinformatics tools. This network allows for a more in-depth analysis of the structural biology of PPIs and furnishes essential insights for the development of targeted small-molecule modulators. Furthermore, this article provides a detailed overview of the research progress and regulatory mechanisms of PPI modulators in M. tuberculosis, the causative agent of TB. Additionally, it summarizes potential targets for anti-TB drugs and discusses the prospects of existing PPI modulators.

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针对结核分枝杆菌蛋白质-蛋白质相互作用的调节剂

结核病（TB）是由（）引起的一种慢性传染病，主要通过飞沫传播感染肺部，严重影响患者的健康和生活质量。临床上，抗结核药物往往存在副作用，对耐药菌株缺乏疗效。因此，探索和开发新型靶向抗结核药物势在必行。目前，蛋白质-蛋白质相互作用（PPIs）为抗结核药物的开发提供了新的途径，而对 PPIs 靶向调节剂的研究已成为一个突出的研究重点。此外，利用计算方法和生物信息学工具构建了一个全面的 PPI 网络。通过该网络可以更深入地分析 PPIs 的结构生物学特性，并为开发靶向小分子调节剂提供重要启示。此外，本文还详细综述了 PPI 调节剂在结核病病原体中的研究进展和调控机制。此外，文章还总结了抗结核药物的潜在靶点，并讨论了现有 PPI 调节剂的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiological research 生物-微生物学

CiteScore

10.90

自引率

6.00%

发文量

249

审稿时长

29 days

期刊介绍： Microbiological Research is devoted to publishing reports on prokaryotic and eukaryotic microorganisms such as yeasts, fungi, bacteria, archaea, and protozoa. Research on interactions between pathogenic microorganisms and their environment or hosts are also covered.