{"title":"Recent developments in the chemistry of Negishi coupling: a review","authors":"Muzammil, Ameer Fawad Zahoor, Bushra Parveen, Sadia Javed, Rabia Akhtar, Shaheera Tabassum","doi":"10.1007/s11696-024-03369-7","DOIUrl":null,"url":null,"abstract":"<div><p>Negishi cross-coupling reaction is a familiar reaction for the formation of carbon–carbon bonds that couples organic halides or triflates with organozinc compounds. Palladium is used as a metal catalyst, sometimes nickel can also be used, e.g. Pd<sub>2</sub>(dba)<sub>3</sub>, PdCl<sub>2</sub>(P(<sup><i>o</i></sup>tol)<sub>3</sub>)<sub>2</sub>, Pd(DPEPhos)Cl<sub>2</sub>, Ni(PPh<sub>3</sub>)<sub>2</sub>Cl<sub>2</sub>, etc. This reaction has vast applications in organic synthesis as many natural products and biologically active compounds can be obtained through this reaction. The main aim of this review is to summarize the recent synthetic applications of the Negishi reaction reported since 2011 which may be helpful to the researchers working on the development of mild and sustainable strategies regarding the synthesis of pharmaceutically important scaffolds.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"78 6","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Papers","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11696-024-03369-7","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Engineering","Score":null,"Total":0}
引用次数: 0
Abstract
Negishi cross-coupling reaction is a familiar reaction for the formation of carbon–carbon bonds that couples organic halides or triflates with organozinc compounds. Palladium is used as a metal catalyst, sometimes nickel can also be used, e.g. Pd2(dba)3, PdCl2(P(otol)3)2, Pd(DPEPhos)Cl2, Ni(PPh3)2Cl2, etc. This reaction has vast applications in organic synthesis as many natural products and biologically active compounds can be obtained through this reaction. The main aim of this review is to summarize the recent synthetic applications of the Negishi reaction reported since 2011 which may be helpful to the researchers working on the development of mild and sustainable strategies regarding the synthesis of pharmaceutically important scaffolds.
Chemical PapersChemical Engineering-General Chemical Engineering
CiteScore
3.30
自引率
4.50%
发文量
590
期刊介绍：
Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.
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