Preparation of calcium phosphate ion clusters through atomization method for biomimetic mineralization of enamel

IF 3.9 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Haide Dong, Lin Qiu, Chen Zhu, Wuzhe Fan, Li Liu, Quanfu Deng, Huan Zhang, Weihu Yang, Kaiyong Cai
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Abstract

Dental enamel is a mineralized extracellular matrix, and enamel defect is a common oral disease. However, the self-repair capacity of enamel is limited due to the absence of cellular components and organic matter. Efficacy of biomimetic enamel mineralization using calcium phosphate ion clusters (CPICs), is an effective method to compensate for the limited self-healing ability of fully developed enamel. Preparing and stabilizing CPICs presents a significant challenge, as the addition of certain stabilizers can diminish the mechanical properties or biosafety of mineralized enamel. To efficiently and safely repair enamel damage, this study quickly prepared CPICs without stabilizers using the atomization method. The formed CPICs were evenly distributed on the enamel surface, prompting directional growth and transformation of hydroxyapatite (HA) crystals. The study revealed that the mended enamel displayed comparable morphology, chemical composition, hardness, and mechanical properties to those of the original enamel. The approach of repairing dental enamel by utilizing ultrasonic nebulization of CPICs is highly efficient and safe, therefore indicating great promise.

通过雾化法制备磷酸钙离子团块,用于珐琅质的生物仿生矿化。
牙釉质是一种矿化的细胞外基质,牙釉质缺损是一种常见的口腔疾病。然而,由于缺乏细胞成分和有机物,牙釉质的自我修复能力有限。利用磷酸钙离子团(CPICs)进行生物仿生珐琅质矿化,是弥补发育完全的珐琅质自我修复能力有限的有效方法。制备和稳定 CPICs 是一项重大挑战,因为添加某些稳定剂会降低矿化珐琅质的机械性能或生物安全性。为了高效安全地修复珐琅质损伤,本研究采用雾化法快速制备了不含稳定剂的 CPIC。形成的 CPIC 均匀地分布在珐琅质表面,促使羟基磷灰石(HA)晶体定向生长和转化。研究表明,修复后的珐琅质在形态、化学成分、硬度和机械性能方面与原始珐琅质相当。利用 CPICs 超声雾化修复牙釉质的方法既高效又安全,因此前景广阔。
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来源期刊
Journal of biomedical materials research. Part A
Journal of biomedical materials research. Part A 工程技术-材料科学:生物材料
CiteScore
10.40
自引率
2.00%
发文量
135
审稿时长
3.6 months
期刊介绍: The Journal of Biomedical Materials Research Part A is an international, interdisciplinary, English-language publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical behavior of materials in physiological environments; and the response of blood and tissues to biomaterials. The Journal publishes peer-reviewed articles on all relevant biomaterial topics including the science and technology of alloys,polymers, ceramics, and reprocessed animal and human tissues in surgery,dentistry, artificial organs, and other medical devices. The Journal also publishes articles in interdisciplinary areas such as tissue engineering and controlled release technology where biomaterials play a significant role in the performance of the medical device. The Journal of Biomedical Materials Research is the official journal of the Society for Biomaterials (USA), the Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Articles are welcomed from all scientists. Membership in the Society for Biomaterials is not a prerequisite for submission.
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