N-terminal processing by dipeptidyl peptidase 9: Cut and Go!

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimie Pub Date : 2024-11-01 DOI:10.1016/j.biochi.2024.03.002

引用次数: 0

Abstract

Dipeptidyl peptidase 9 (DPP9) is an intracellular amino-dipeptidase with physiological roles in the immune system, DNA repair and mitochondria homeostasis, while its deregulation is linked to cancer progression and immune-associated defects. Through its rare ability to cleave a peptide bond following the imino-acid proline, DPP9 acts as a molecular switch that regulates key proteins, such as the tumor-suppressor BRCA2. In this review we will discuss key concepts underlying the outcomes of protein processing by DPP9, including substrate turn-over by the N-degron pathway. Additionally, we will review non-enzymatic roles and the regulation of DPP9 by discussing the interactome of this protease, which includes SUMO1, Filamin A, NLRP1 and CARD8.

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二肽基肽酶 9 的 N 末端处理：剪切和转运！

二肽基肽酶 9（DPP9）是一种细胞内氨基二肽酶，在免疫系统、DNA 修复和线粒体稳态中发挥着生理作用，而其失调则与癌症进展和免疫相关缺陷有关。DPP9 具有一种罕见的能力，能在亚胺酸脯氨酸之后裂解肽键，从而充当调节肿瘤抑制因子 BRCA2 等关键蛋白的分子开关。在这篇综述中，我们将讨论 DPP9 蛋白加工结果的关键概念，包括 N-降解子途径的底物翻转。此外，我们还将通过讨论这种蛋白酶的相互作用组（包括 SUMO1、Filamin A、NLRP1 和 CARD8）来回顾 DPP9 的非酶作用和调控。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimie 生物-生化与分子生物学

CiteScore

7.20

自引率

2.60%

发文量

219

审稿时长

40 days

期刊介绍： Biochimie publishes original research articles, short communications, review articles, graphical reviews, mini-reviews, and hypotheses in the broad areas of biology, including biochemistry, enzymology, molecular and cell biology, metabolic regulation, genetics, immunology, microbiology, structural biology, genomics, proteomics, and molecular mechanisms of disease. Biochimie publishes exclusively in English. Articles are subject to peer review, and must satisfy the requirements of originality, high scientific integrity and general interest to a broad range of readers. Submissions that are judged to be of sound scientific and technical quality but do not fully satisfy the requirements for publication in Biochimie may benefit from a transfer service to a more suitable journal within the same subject area.