Effect of nanocurcumin on fertility in murine model of polycystic ovary syndrome.

IF 0.8 4区农林科学 Q3 ZOOLOGY

Veterinary Research Forum Pub Date : 2024-01-01 Epub Date: 2024-02-15 DOI:10.30466/vrf.2023.2006604.3935

Zahra Aaly-Gharibeh, Mohammadreza Hosseinchi, Ali Shalizar-Jalali

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Abstract

The precise pathophysiology of polycystic ovary syndrome (PCOS) is not well-founded. In an attempt to fill this gap, the current study was executed to probe the effect of nanocurcumin (NCC) on ovarian tissue, in vitro fertilization (IVF) and pre-implantation embryo development in a mouse model of PCOS. Fifty adult female mice were randomly categorized into five equal groups including non-treated control and PCOS (receiving 0.20 mg estradiol valerate (EV) intra-peritoneally once a day for 21 days) as well as NCC_12.50 + PCOS, NCC₂₅ + PCOS and NCC₅₀ + PCOS (receiving respectively 12.50, 25.00 and 50.00 mg kg^-1 NCC daily along with EV injection through oral gavages for 21 days) groups. Subsequently, ovarian histo-architecture and total anti-oxidant capacity, and malonaldehyde and catalase levels as well as in vitro fertilizing potential, early embryonic development and serum testosterone concentration were analyzed. Results showed that NCC in a dose-dependent manner improved ovarian cyto-architectural organization and oxidant/anti-oxidant balance along with IVF rate and pre-implantation embryo development in PCOS mice. These findings revealed that NCC at the doses of 25.00 and 50.00 mg kg^-1 could alleviate PCOS-linked reproductive disruptions in female mice.

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纳米姜黄素对多囊卵巢综合征小鼠模型生育力的影响

多囊卵巢综合征（PCOS）的确切病理生理学尚未得到充分证实。为了填补这一空白，本研究以多囊卵巢综合征小鼠模型为研究对象，探讨了纳米姜黄素（NCC）对卵巢组织、体外受精（IVF）和植入前胚胎发育的影响。50 只成年雌性小鼠被随机分为五个等量组，包括未经治疗的对照组、多囊卵巢综合征组（每天腹腔注射一次 0.20 毫克戊酸雌二醇（EV），连续 21 天）以及 NCC12.50 + 多囊卵巢综合征组、NCC25 + 多囊卵巢综合征组和 NCC50 + 多囊卵巢综合征组（每天分别注射 12.50、25.00 和 50.00 毫克 kg-1 NCC，同时口服注射 EV，连续 21 天）。随后，对卵巢组织结构、总抗氧化能力、丙二醛和过氧化氢酶水平以及体外受精潜能、早期胚胎发育和血清睾酮浓度进行了分析。结果表明，NCC以剂量依赖的方式改善了多囊卵巢综合征小鼠的卵巢细胞结构组织、氧化剂/抗氧化剂平衡、体外受精率和着床前胚胎发育。这些研究结果表明，25.00 和 50.00 mg kg-1 剂量的 NCC 可减轻 PCOS 导致的雌性小鼠生殖障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary Research Forum Veterinary-General Veterinary

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Veterinary Research Forum (VRF) is a quarterly international journal committed to publish worldwide contributions on all aspects of veterinary science and medicine, including anatomy and histology, physiology and pharmacology, anatomic and clinical pathology, parasitology, microbiology, immunology and epidemiology, food hygiene, poultry science, fish and aquaculture, anesthesia and surgery, large and small animal internal medicine, large and small animal reproduction, biotechnology and diagnostic imaging of domestic, companion and farm animals.