Envisioning the Future: Nanomicelles Revolutionizing Ocular Drug Delivery.

Q2 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical nanotechnology Pub Date : 2024-03-08 DOI:10.2174/0122117385286925240221111601

Chetna Modi, Varsha Gadhvi, Bhupendra G Prajapati

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引用次数: 0

Abstract

Due to the complexities of the eye's anatomy and physiology, achieving targeted drug delivery with minimal harm to healthy eye tissues has proven to be difficult. The focus of the review is on the potential of lipid and polymer micelle-based drug delivery systems, specifically nanomicelles, to overcome these challenges and improve the absorption of insoluble drugs. Nanomicelles offer several advantages, such as enhanced drug release kinetics, increased drug incorporation, and improved formulation of hydrophobic medicines. The review provides insights into various excipients, preparation methods, and evaluation techniques used in nanomicellar-based drug delivery systems. Furthermore, the review highlights current research and patents related to nanomicelles in ocular drug delivery, suggesting growing interest and potential for future developments in this field. Nanomicelles present a promising approach that may revolutionize ocular drug delivery and open new possibilities for treating various ocular diseases while minimizing adverse effects on healthy eye tissues.

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展望未来：纳米细胞为眼部给药带来革命性变化。

由于眼睛的解剖和生理结构复杂，要实现靶向给药并将对健康眼睛组织的伤害降到最低已被证明十分困难。本综述的重点是基于脂质和聚合物胶束的给药系统（特别是纳米胶束）在克服这些挑战和改善不溶性药物吸收方面的潜力。纳米胶束具有多种优势，如增强药物释放动力学、增加药物掺入量和改进疏水性药物的配制。本综述深入介绍了基于纳米微囊的给药系统中使用的各种辅料、制备方法和评估技术。此外，综述还重点介绍了眼部给药中与纳米微囊相关的当前研究和专利，表明了人们对这一领域日益增长的兴趣和未来发展的潜力。纳米微囊是一种前景广阔的方法，可能会彻底改变眼部给药方式，为治疗各种眼部疾病提供新的可能性，同时最大限度地减少对健康眼部组织的不利影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical nanotechnology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.20

自引率

0.00%

发文量

期刊介绍： Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.