Nutrition Status Plays a Partial Mediation Role in the Relationship between Number of Teeth and Frailty: A Cross-Sectional Multicenter Study.

IF 3.1 3区医学 Q3 GERIATRICS & GERONTOLOGY

Gerontology Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI:10.1159/000538181

Xin Xia, Zhongli Yang, Zhigang Xu, Jingyi Tang, Gongchang Zhang, Birong Dong, Xiaolei Liu

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引用次数: 0

Abstract

Introduction: Although the relationship between the number of teeth and frailty has been extensively studied, the mediating role of nutrition status in the association between the number of teeth and frailty remains to be clarified.

Methods: A number of 6,664 participants lived in the communities of West China were analyzed in our study. Physical frailty was determined based on the phenotype established by Fried. Nutrition status was evaluated using the Mini Nutrition Assessment-Short Form (MNA-SF) scale. Multiple linear regression was employed to evaluate the direct relationships between the number of teeth, nutrition, and frailty. Mediation models and structural equation model (SEM) pathway analysis were used to test the mediating role of nutrition status in the relationship between the number of teeth and frailty.

Results: Among the 6,664 participants aged over 50 years old, the prevalence of frailty was 6.2%. Multiple linear regression analysis showed a significant total relationship between the number of teeth (β = -0.359, 95% CI: -0.473 to -0.244, p < 0.001) and frailty. After adjusting for MNA-SF scores, the relationship between the number of teeth and frailty remained significant (β = -0.327, 95% CI: -0.443 to -0.211, p < 0.001), indicating a partial mediating effect of nutrition. Mediation analysis verified that nutrition partially mediated the relationship between the number of teeth and frailty (indirect effect estimate = -0.0121, bootstrap 95% CI: -0.0151 to -0.0092; direct effect estimate = -0.0874, bootstrap 95% CI: -0.1086 to -0.0678) in the fully adjusted model. This mediating effect occurred through influencing weight loss, low level of physical activity, and debility. SEM framework pathway analysis confirmed the association between the number of teeth, nutrition, and frailty.

Conclusions: Our findings demonstrated that frailty was correlated with the number of teeth and poorer nutritional status, with nutrition partially mediating the correlation between the number of teeth and frailty. Our results supported early nutritional evaluation and intervention in oral health to decrease the risk of frailty.

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营养状况在牙齿数量与体弱之间的关系中起部分调解作用：一项横断面多中心研究。

引言虽然牙齿数量与体弱之间的关系已被广泛研究，但营养状况在牙齿数量与体弱之间的关系中的中介作用仍有待明确。方法我们的研究分析了居住在中国西部社区的 6664 名参与者。体质虚弱是根据弗里德建立的表型确定的。营养状况采用迷你营养评估短表（MNA-SF）量表进行评估。采用多元线性回归评估牙齿数量、营养和虚弱之间的直接关系。采用中介模型和结构方程模型（SEM）路径分析来检验营养状况在牙齿数量与虚弱之间关系中的中介作用。结果在 6664 名 50 岁以上的参与者中，体弱的发生率为 6.2%。多元线性回归分析表明，牙齿数量（β = -0.359，95% CI：-0.473 至 -0.244，p < 0.001）与体弱之间存在显著的总体关系。在对 MNA-SF 评分进行调整后，牙齿数量与虚弱之间的关系仍然显著（β= -0.327，95% CI：-0.443 至 -0.211，p <0.001），表明营养具有部分中介效应。中介分析证实，在完全调整模型中，营养部分中介了牙齿数量与虚弱之间的关系（间接效应估计值=-0.0121，bootstrap 95% CI：-0.0151 至-0.0092；直接效应估计值=-0.0874，bootstrap 95% CI：-0.1086 至-0.0678）。这种中介效应是通过影响体重减轻、体力活动水平低和衰弱产生的。结构方程模型（SEM）框架路径分析证实了牙齿数量、营养和虚弱之间的关联。结论我们的研究结果表明，虚弱与牙齿数量和较差的营养状况有关，营养状况在一定程度上介导了牙齿数量和虚弱之间的相关性。我们的研究结果支持尽早进行营养评估和口腔健康干预，以降低虚弱的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gerontology 医学-老年医学

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.