Motoric Cognitive Risk Syndrome and the Risk of Incident Dementia: A Systematic Review and Meta-Analysis of Cohort Studies.

IF 3.1 3区医学 Q3 GERIATRICS & GERONTOLOGY

Gerontology Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI:10.1159/000535082

Weihao Xu, Anying Bai, Yuanfeng Liang, Zhanyi Lin

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引用次数: 0

Abstract

Background: Epidemiologic studies have indicated an association of motoric cognitive risk syndrome (MCR), a pre-dementia stage characterized by the presence of cognitive complaints and a slow gait, with increased risk of incident dementia.

Objectives: We aimed to clarify this association using meta-analysis.

Methods: We systematically searched the PubMed, Embase, and Web of Science databases up to December 2022 for relevant studies that investigated the association between MCR and incident all-cause dementia and Alzheimer's disease (AD). The random-effects model was used to determine a pooled-effect estimate of the association.

Results: We identified seven articles that corresponded with nine cohort studies investigating the association between MCR and the risk of dementia. Pooled analysis showed that MCR was associated with a significantly increased risk of incident all-cause dementia (HR = 2.28; 95% CI: 1.90-2.73) and AD (HR = 2.05; 95% CI: 1.61-2.61). Sensitivity analysis showed that there was no evidence that individual studies influenced the pooled-effect estimate, verifying the robustness of the results.

Conclusions: Our results confirm that MCR is an independent risk factor of incident all-cause dementia and AD. Future studies are needed to better understand the mechanisms underlying this association.

查看原文本刊更多论文

运动性认知风险综合征与痴呆症发病风险：队列研究的系统回顾和荟萃分析。

背景流行病学研究表明，运动性认知风险综合征（MCR）与痴呆症发病风险的增加存在关联，运动性认知风险综合征是痴呆症的前期阶段，其特点是存在认知抱怨和步态缓慢。目的我们旨在通过荟萃分析来澄清这种关联。方法我们在 PubMed、Embase 和 Web of Science 数据库中系统检索了截至 2022 年 12 月调查 MCR 与全因痴呆症和阿尔茨海默病（AD）发病关系的相关研究。研究采用随机效应模型确定相关性的集合效应估计值。结果我们发现了 7 篇文章，对应 9 项队列研究，调查了 MCR 与痴呆症风险之间的关系。汇总分析表明，MCR 与全因痴呆症（HR=2.28；95% CI：1.90-2.73）和注意力缺失症（HR=2.05；95% CI：1.61-2.61）的发病风险显著增加有关。敏感性分析表明，没有证据表明个别研究影响了集合效应估计值，这验证了结果的稳健性。结论我们的研究结果证实，MCR 是导致全因痴呆症和注意力缺失症的独立风险因素。为了更好地了解这种关联的内在机制，还需要进行进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gerontology 医学-老年医学

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.