Factor V Leiden, MTHFR, and FXIIIVal34Leu gene polymorphisms and their association with clinical features and risk of diabetic retinopathy in patients with type 2 diabetes.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI:10.22088/cjim.15.1.11

Atefeh Rahimi, Nastaran Moridi, Amin Golestani, Gholamreza Anani-Sarab, Fatemeh Salmani, Gholamhossein Yaqubi, Behzad Mesbahzadeh, Mohammad Ali Jalalifar, Mohammad Malekaneh, Seyed Mehdi Sajjadi

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Abstract

Background: Diabetic retinopathy (DR) is expanding to epidemic levels globally due to the progressing prevalence of diabetes mellitus (DM). In this study, the association between factor V Leiden (FVL), MTHFRC677T, and FXIIIVal34Leu polymorphisms and diabetic retinopathy was investigated in Eastern Iran.

Methods: This case-control study enlisted the participation of 300 people (diabetic patients=100, diabetic retinopathy patients=100, healthy controls=100), and polymorphisms were examined by Tetra primer ARMS-PCR.

Results: The frequency of FVL (p=0.294) and FXIIIVal34Leu (P=0.349) polymorphism showed no significant results between the genotype frequency in the mentioned groups. In contrast, MTHFRC677T SNP was significantly different in diabetic patients and controls (P=0.008). The MTHFRC677T polymorphism was found to be connected with increased systolic blood pressure in patients who had the TT genotype (130.96±11.92mm/Hg; P=0.011).

Conclusion: Our study recommended that the MTHFRC677T polymorphism may offer to DR development. Studies with larger sample sizes and a wider spectrum of populations are authorized to verify this finding.

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因子 V Leiden、MTHFR 和 FXIIIVal34Leu 基因多态性及其与 2 型糖尿病患者临床特征和糖尿病视网膜病变风险的关系。

背景：由于糖尿病（DM）的发病率不断上升，糖尿病视网膜病变（DR）正在全球范围内蔓延。本研究调查了伊朗东部地区因子 V Leiden（FVL）、MTHFRC677T 和 FXIIIVal34Leu 多态性与糖尿病视网膜病变之间的关系：这项病例对照研究有 300 人参与（糖尿病患者=100 人，糖尿病视网膜病变患者=100 人，健康对照组=100 人），并通过 Tetra 引物 ARMS-PCR 对多态性进行了检测：结果：FVL（P=0.294）和FXIIIVal34Leu（P=0.349）多态性在上述组别中的基因型频率之间无显著差异。相比之下，MTHFRC677T SNP 在糖尿病患者和对照组中存在显著差异（P=0.008）。研究发现，MTHFRC677T 多态性与 TT 基因型患者的收缩压升高有关（130.96±11.92mm/Hg；P=0.011）：我们的研究表明，MTHFRC677T 多态性可能会导致 DR 的发生。为了验证这一发现，需要进行样本量更大、涉及人群更广的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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