The relationship between long non-coding gene CASC21 polymorphisms and cervical cancer.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-12-31 Epub Date: 2024-03-11 DOI:10.1080/15384047.2024.2322207

Lili Han, Jing Liu, Mireayi Shataer, Chengyong Wu, Mayinuer Niyazi

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引用次数: 0

Abstract

Background: CASC21 was reported to be a hotspot gene in cervical cancer. The relationship between CASC21 genetic polymorphisms and cervical cancer has not been reported. Genetic factors influence the occurrence of cervical cancer. Thus, we explored the correlation between CASC21 polymorphisms and cervical cancer.

Methods: A total of 973 participants within 494 cervical cancer cases and 479 healthy controls were recruited. Five single nucleotide polymorphisms (SNPs) in the CASC21 gene were genotyped using the Agena MassARRAY platform. Chi-squared test, logistic regression analysis, odds ratio (OR), multifactor dimensionality reduction (MDR), and 95% confidence interval (95%CI) were used for data analysis.

Results: In the overall analysis, rs16902094 (p = .014, OR = 1.86, 95% CI = 1.12-3.08) and rs16902104 (p = .014, OR = 1.86, 95% CI = 1.12-3.09) had the risk-increasing correlation with the occurrence of cervical cancer. Stratification analysis showed that rs16902094 and rs16902104 were still associated with cervical cancer risk in the subgroups with age > 51, BMI < 24 kg/m², smokers, and patients with cervical squamous cell carcinoma. MDR analysis displayed that rs16902094 (.49%) and rs16902104 (.52%) were the main influential attribution factor for cervical cancer risk.

Conclusion: Our finding firstly determined that two CASC21 SNPs (rs16902094, rs16902104) were associated with an increased risk of cervical cancer, which adds to our knowledge regarding the effect of CASC21 on cervical carcinogenesis.

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长非编码基因 CASC21 多态性与宫颈癌的关系

背景：据报道，CASC21 是宫颈癌的热点基因。CASC21 基因多态性与宫颈癌之间的关系尚未见报道。遗传因素会影响宫颈癌的发生。因此，我们探讨了 CASC21 基因多态性与宫颈癌之间的相关性：方法：在 494 例宫颈癌病例和 479 例健康对照中招募了 973 名参与者。使用 Agena MassARRAY 平台对 CASC21 基因中的五个单核苷酸多态性（SNPs）进行了基因分型。数据分析采用了卡方检验、逻辑回归分析、几率比（OR）、多因素降维（MDR）和95%置信区间（95%CI）：在总体分析中，rs16902094（p = .014，OR = 1.86，95% CI = 1.12-3.08）和rs16902104（p = .014，OR = 1.86，95% CI = 1.12-3.09）与宫颈癌的发生具有风险递增相关性。分层分析表明，在年龄大于 51 岁、体重指数为 2、吸烟者和宫颈鳞状细胞癌患者的亚组中，rs16902094 和 rs16902104 仍与宫颈癌风险相关。MDR分析显示，rs16902094（.49%）和rs16902104（.52%）是宫颈癌风险的主要影响因素：我们的发现首次确定了两个CASC21 SNPs（rs16902094和rs16902104）与宫颈癌风险的增加相关，这增加了我们关于CASC21对宫颈癌发生影响的知识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.