PROBIOTICS FOR PREVENTION OF NECROTIZING ENTEROCOLITIS : A COMPREHENSIVE SYSTEMATIC REVIEW

Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425) Pub Date : 2024-03-01 DOI:10.61841/at14a173

Syarifah Tiara Aisyah Sabrina, Eza Melinda, Muchammad Jalaluddin Machalli

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Abstract

Background: Necrotizing enterocolitis (NEC) is the most common serious acquired disease of the gastrointestinal tract in preterm infants. It is characterized by bowel wall necrosis, of various length and depth. Bowel perforation occurs in one third of the affected infants. Although 5 to 25 of cases occur in term infants, it is primarily a disease of preterm infants with the majority of cases occurring in very low birth weight infants (infants with birth weight 1500 g). The aim: This study aims to show about probiotics for prevention of nercrotizing enterocolitis. Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done. Result: In the PubMed database, the results of our search brought up 26 articles, whereas the results of our search on SagePub brought up 48 articles, on Google Scholar 5660 articles. The results of the search conducted for the last year of 2014 yielded a total 15 articles for PubMed, 35 articles for SagePub, and 4567 articles for Google Scholar. The result from title screening, a total 11 articles for PubMed, 16 articles for SagePub, and 8 for Google Scholar. In the end, we compiled a total of 10 papers. We included five research that met the criteria. Conclusion: The risk-benefit ratio depends on the incidence of NEC in a neonatal intensive care unit, and evidence has shown that preventive measures probiotic administration can result in a decrease in NEC.

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预防坏死性小肠结肠炎的益生菌：全面系统综述

背景：坏死性小肠结肠炎（NEC坏死性小肠结肠炎（NEC）是早产儿胃肠道最常见的严重后天性疾病。其特点是肠壁坏死，坏死长度和深度不一。三分之一的患儿会发生肠穿孔。虽然有 5 到 25 例发生在足月儿身上，但它主要是早产儿的一种疾病，大多数病例发生在极低出生体重儿（出生体重 1500 克的婴儿）身上。目的：本研究旨在说明益生菌对预防小肠结肠炎的作用。方法：通过与《2020 年系统综述和荟萃分析首选报告项目》（PRISMA）所设定的标准进行比较，本研究表明其符合所有要求。因此，专家们能够确保该研究尽可能是最新的。在这种搜索方法中，2014 年至 2024 年间发表的出版物被纳入考虑范围。为此，我们使用了多个不同的在线参考资料来源，如 Pubmed 和 SagePub。决定不考虑评论文章、已发表的作品或仅完成一半的作品。结果在 PubMed 数据库中，我们搜索到 26 篇文章，而在 SagePub 上搜索到 48 篇文章，在 Google Scholar 上搜索到 5660 篇文章。2014 年最后一年的检索结果显示，PubMed 共检索到 15 篇文章，SagePub 共检索到 35 篇文章，Google Scholar 共检索到 4567 篇文章。标题筛选结果显示，PubMed 共收录 11 篇文章，SagePub 共收录 16 篇文章，Google Scholar 共收录 8 篇文章。最后，我们共整理出 10 篇论文。我们收录了五项符合标准的研究。结论风险效益比取决于新生儿重症监护室中 NEC 的发生率，有证据表明，使用益生菌预防措施可减少 NEC 的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425)

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