On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review

IF 3.4 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical Pub Date : 2024-01-01 DOI:10.1016/j.nicl.2024.103589

Noa van der Knaap , Marcel J.H. Ariës , Iwan C.C. van der Horst , Jacobus F.A. Jansen

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引用次数: 0

Abstract

Many Coronavirus Disease 2019 (COVID-19) patients are suffering from long-term neuropsychological sequelae. These patients may benefit from a better understanding of the underlying neuropathophysiological mechanisms and identification of potential biomarkers and treatment targets. Structural clinical neuroimaging techniques have limited ability to visualize subtle cerebral abnormalities and to investigate brain function. This scoping review assesses the merits and potential of advanced neuroimaging techniques in COVID-19 using literature including advanced neuroimaging or postmortem analyses in adult COVID-19 patients published from the start of the pandemic until December 2023. Findings were summarized according to distinct categories of reported cerebral abnormalities revealed by different imaging techniques. Although no unified COVID-19-specific pattern could be subtracted, a broad range of cerebral abnormalities were revealed by advanced neuroimaging (likely attributable to hypoxic, vascular, and inflammatory pathology), even in absence of structural clinical imaging findings. These abnormalities are validated by postmortem examinations. This scoping review emphasizes the added value of advanced neuroimaging compared to structural clinical imaging and highlights implications for brain functioning and long-term consequences in COVID-19.

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关于 COVID-19 中先进神经成像技术的优点和潜力：范围审查

许多冠状病毒病 2019（COVID-19）患者都患有长期的神经心理后遗症。更好地了解潜在的神经病理生理学机制并确定潜在的生物标志物和治疗靶点可能会使这些患者受益。结构性临床神经成像技术在观察细微的大脑异常和研究大脑功能方面能力有限。本范围综述利用从大流行开始到 2023 年 12 月期间发表的文献，包括对 COVID-19 成人患者进行的高级神经成像或尸检分析，评估了高级神经成像技术在 COVID-19 中的优点和潜力。根据不同成像技术所显示的脑部异常报告的不同类别对研究结果进行了总结。虽然没有统一的 COVID-19 特异模式，但先进的神经成像技术发现了广泛的大脑异常（可能归因于缺氧、血管和炎症病理），即使没有结构性临床成像结果也是如此。死后检查也验证了这些异常。本范围综述强调了高级神经成像与临床结构成像相比所具有的附加价值，并突出了 COVID-19 对大脑功能和长期后果的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroimage-Clinical NEUROIMAGING-

CiteScore

7.50

自引率

4.80%

发文量

368

审稿时长

52 days

期刊介绍： NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging. The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.