S. N. Myakisheva, Y. L. Baburina, M. I. Kobyakova, R. R. Krestinin, L. D. Sotnikova, O. V. Krestinina
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引用次数: 0
Abstract
The effects of sodium diethyldithiocarbamate, melatonin, and their combined use on proliferative activity, changes in cytosolic Ca2+, membrane potential, and production of reactive oxygen species in the culture of mouse N1E-115 neuroblastoma cells (clone C-1300) were studied. Sodium diethyldithiocarbamate and melatonin have been shown to inhibit proliferation and enhance cell differentiation. At the same time, the content of the anti-apoptotic protein Bcl-2 decreased, while the content of the pro-apoptotic protein Bax increased, which might suggest the launch of an apoptotic cascade. However, the use of these two drugs together did not enhance the observed effects. Apparently, the mechanisms by which diethyldithiocarbamates and melatonin acted on cells were different.
BiophysicsBiochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍：
Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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