Applications of samarium complexes as cytotoxic, bioimaging and DNA interacting agents: a comprehensive review

IF 4.1 3区 化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR
Poonam R. Inamdar, Shashikant Bhandari, Mrunalini Kulkarni, Neeta Rai, Anuja Kolsure
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引用次数: 0

Abstract

Cisplatin coined a term Metallodrug and later a tradition of Metallodrugs was established. Later, severe renal and metabolic toxicities of the platinum based drugs prompted the medicinal chemists to develop new and novel metallotherapeutics with different metal cores. Henceforth, chemists designed the metal complexes based on copper, cobalt, vanadium iron and zinc. These complexes were reported for their antibacterial, anticancer, antidiabetic and enzyme inhibitors. Later, chemists also focused on lanthanide metal ions and resulted in the design of metal complexes for the application of bio imaging cellular studies as well as chemotherapeutic agents. This review throws a light on the recent advances in the development of the samarium complexes as efficient and versatile biological agents. Samarium complexes based on various ligand systems and ancillary ligands have been mentioned in this review stating their biological efficacy and potency against variable cancer cell lines, their DNA interactive behaviour.
钐配合物在细胞毒性、生物成像和 DNA 相互作用剂方面的应用:全面综述
顺铂(Cisplatin)创造了 "金属药物"(Metallodrug)这一术语,随后金属药物的传统便建立起来。后来,铂类药物严重的肾毒性和代谢毒性促使药物化学家们开发出具有不同金属内核的新型金属治疗药物。因此,化学家们设计出了基于铜、钴、钒铁和锌的金属复合物。据报道,这些配合物具有抗菌、抗癌、抗糖尿病和酶抑制作用。后来,化学家们又把目光投向了镧系金属离子,并设计出了用于生物成像细胞研究和化疗药物的金属复合物。本综述介绍了钐配合物作为高效、多用途生物制剂的最新进展。本综述提到了基于各种配体系统和辅助配体的钐配合物,并说明了它们对不同癌细胞系的生物功效和效力,以及它们的 DNA 交互作用行为。
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来源期刊
Reviews in Inorganic Chemistry
Reviews in Inorganic Chemistry 化学-分析化学
CiteScore
7.30
自引率
4.90%
发文量
20
审稿时长
1 months
期刊介绍: Reviews in Inorganic Chemistry (REVIC) is a quarterly, peer-reviewed journal that focuses on developments in inorganic chemistry. Technical reviews offer detailed synthesis protocols, reviews of methodology and descriptions of apparatus. Topics are treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are committed to high quality standards and rapid handling of the review and publication process. The journal publishes all aspects of solid-state, molecular and surface chemistry. Topics may be treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are commited to high quality standards and rapid handling of the review and publication process. Topics: -Main group chemistry- Transition metal chemistry- Coordination chemistry- Organometallic chemistry- Catalysis- Bioinorganic chemistry- Supramolecular chemistry- Ionic liquids
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