Inhalation of High Doses of Gaseous Nitric Oxide in HIV Infection

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology
A. V. Pekshev, A. B. Vagapov, N. A. Sharapov, A. F. Vanin
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Abstract

The therapeutic effect of high-dose inhalation of nitrogen oxide gas (at a NO concentration of at least 1000 ppm) in two HIV-infected patients was demonstrated. Inhaled NO therapy led to a rapid decrease in viral load to an undetectable level, which persisted even after the period of analytical interruption of treatment. It was assumed that the relief of HIV infection was due to nitrosonium cations NO+ formed in the blood from neutral NO molecules. The subsequent conversion of NO+ cations in their reaction with hydroxyl anions into nitrite anions was prevented by the binding of NO+ cations with chlorine anions and the formation of nitrosochloride in the blood. The entry of this agent from the blood into cells and tissues provided the transfer of NO+ cations into them. The interaction of nitrosochloride with thiols could lead to the appearance of corresponding S-nitrosothiols in cells and tissues as NO donors.

Abstract Image

Abstract Image

在艾滋病毒感染中吸入高剂量的一氧化氮气体
摘要 在两名艾滋病毒感染者身上证实了大剂量吸入氧化氮气体(氧化氮浓度至少为 1000 ppm)的治疗效果。吸入氮氧化物疗法使病毒载量迅速下降到检测不到的水平,甚至在分析性中断治疗后仍能持续。据推测,艾滋病毒感染的缓解是由于中性 NO 分子在血液中形成了亚硝鎓阳离子 NO+。随后,NO+阳离子与羟基阴离子反应转化为亚硝酸阴离子,NO+阳离子与氯阴离子结合并在血液中形成亚硝基盐酸盐,从而阻止了亚硝酸阴离子的转化。这种物质从血液进入细胞和组织后,可将 NO+ 阳离子转移到细胞和组织中。亚硝基盐酸盐与硫醇的相互作用可导致细胞和组织中出现相应的 S-亚硝基硫醇,成为一氧化氮的供体。
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来源期刊
Biophysics
Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍: Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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