Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis

IF 6.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Weiqian Cao
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引用次数: 0

Abstract

Glycoproteome analysis at a site-specific level and proteome scale stands out as a highly promising approach for gaining insights into the intricate roles of glycans in biological systems. Recent years have witnessed an upsurge in the development of innovative methodologies tailored for precisely this purpose. Breakthroughs in mass spectrometry–based glycoproteomic techniques, enabling the identification, quantification, and systematic exploration of site-specific glycans, have significantly enhanced our capacity to comprehensively and thoroughly characterize glycoproteins. In this short review, we delve into novel tools in advancing site-specific glycoproteomic analysis and summarize pertinent studies published in the past two years. Lastly, we discuss the ongoing challenges and outline future prospects in the field, considering both the analytical strategies of mass spectrometry and the tools employed for data interpretation.

推进基于质谱技术的糖蛋白组软件工具,以进行全面的特定位点糖蛋白组分析
在特定位点水平和蛋白质组范围内进行糖蛋白组分析,是一种极具前景的方法,有助于深入了解糖在生物系统中的复杂作用。近年来,为实现这一目标而开发的创新方法急剧增加。基于质谱技术的糖蛋白组学技术取得了突破性进展,能够对特定位点的聚糖进行鉴定、定量和系统探索,大大提高了我们全面、彻底地描述糖蛋白特征的能力。在这篇简短的综述中,我们将深入探讨推进位点特异性糖蛋白组分析的新型工具,并总结过去两年中发表的相关研究。最后,我们从质谱分析策略和数据解读工具两方面讨论了该领域目前面临的挑战,并概述了该领域的未来前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Opinion in Chemical Biology
Current Opinion in Chemical Biology 生物-生化与分子生物学
CiteScore
13.30
自引率
1.30%
发文量
113
审稿时长
74 days
期刊介绍: COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.
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