Blood compatibility of poly(propylene glycol diester) and its water structure observed by differential scanning calorimetry and ²H-nuclear magnetic resonance spectroscopy.

IF 3.6 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-06-01 Epub Date: 2024-03-08 DOI:10.1080/09205063.2024.2324505

Akira Mochizuki, Ayaka Udagawa, Yuko Miwa, Yoshiki Oda, Konatsu Yoneyama, Chihiro Okuda

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引用次数: 0

Abstract

Recently, we applied solution ²H-nuclear magnetic resonance spectroscopy (²H NMR) to analyze the water (deuterium oxide, D₂O) structure in several biopolymers at ambient temperature. We established that polymers with good blood compatibility (i.e. poly(2-methoxyethyl acrylate) (PMEA)) have water observed at high magnetic fields (upfield) compared with bulk water. Polymers containing poly(propylene glycol) (PPG) or poly(propylene oxide) (PPO) exhibit good compatibility; however, the reason for this remains unclear. In addition, reports on the blood compatibility of PPO/PPG are limited. Therefore, PPG diester (PPGest) was prepared as a model polymer, and its blood compatibility and water structure were investigated. PPGest exhibited excellent blood compatibility. The water in PPGest was observed upfield by ²H NMR, and it was defined as non-freezing water via differential scanning calorimetry. Based on these observations, the relationship between the blood compatibility and water structure of PPGest is discussed by comparing with those of PMEA, and the reason for the good performance of PPG/PPO-based polymers is discussed.

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通过差示扫描量热法和 2H 核磁共振谱观察聚丙二醇二酯的血液相容性及其水结构。

最近，我们应用溶液 2H 核磁共振光谱（2H NMR）分析了几种生物聚合物在环境温度下的水（氧化氘，D2O）结构。我们发现，与块状水相比，血液相容性好的聚合物（如聚（2-甲氧基乙基丙烯酸酯）（PMEA））在高磁场（上场）下能观察到水。含有聚（丙二醇）（PPG）或聚（环氧丙烷）（PPO）的聚合物表现出良好的相容性，但其原因仍不清楚。此外，有关 PPO/PPG 血液相容性的报道也很有限。因此，我们制备了 PPG 二酯（PPGest）作为模型聚合物，并对其血液相容性和水结构进行了研究。PPGest 表现出优异的血液相容性。通过 2H NMR 可以观察到 PPGest 中的水在上场，并通过差示扫描量热法将其定义为不冻水。基于这些观察结果，通过与 PMEA 进行比较，讨论了 PPGest 的血液相容性和水结构之间的关系，并探讨了 PPG/PPO 基聚合物具有良好性能的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomaterials Science, Polymer Edition 工程技术-材料科学：生物材料

CiteScore

7.10

自引率

5.60%

发文量

117

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Science, Polymer Edition publishes fundamental research on the properties of polymeric biomaterials and the mechanisms of interaction between such biomaterials and living organisms, with special emphasis on the molecular and cellular levels. The scope of the journal includes polymers for drug delivery, tissue engineering, large molecules in living organisms like DNA, proteins and more. As such, the Journal of Biomaterials Science, Polymer Edition combines biomaterials applications in biomedical, pharmaceutical and biological fields.