Inverse associations of cord blood mitochondrial DNA copy number with childhood adiposity

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2024-03-07 DOI:10.1002/oby.24005

Aalekhya Reddam, Tessa R. Bloomquist, Lindsey T. Covell, Heng Hu, Sharon E. Oberfield, Dympna Gallagher, Rachel L. Miller, Jeff Goldsmith, Andrew G. Rundle, Andrea A. Baccarelli, Julie B. Herbstman, Allison Kupsco

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引用次数: 0

Abstract

Objective

The objective of this study was to examine associations between umbilical cord mitochondrial DNA copy number (mtDNAcn) and adiposity across childhood.

Methods

In a prospective birth cohort of Dominican and African American children from New York City, New York (1998–2006), mtDNAcn was measured in cord blood. Children (N = 336) were evaluated for their height, weight, and bioimpedance at age 5, 7, 9, and 11 years. We used linear mixed-effects models to assess associations of mtDNAcn tertiles in cord blood with child BMI, BMI z scores, fat mass index, and body fat percentage. Latent class growth models and interactions between mtDNAcn and child age or child age² were used to assess associations between age and adiposity trajectories.

Results

BMI was, on average, 1.5 kg/m² higher (95% CI: 0.58, 2.5) in individuals with mtDNAcn in the low- compared with the middle-mtDNAcn tertile. Results were similar for BMI z score, fat mass index, and body fat percentage. Moreover, children in the low-mtDNAcn group had increased odds of being in an “increasing” or “high-stable” adiposity class.

Conclusions

Lower mtDNAcn at birth may predict greater childhood adiposity, highlighting the potential key role of perinatal mitochondrial function in adiposity during development.

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脐带血线粒体 DNA 拷贝数与儿童肥胖的反向关系。

研究目的本研究旨在探讨脐带线粒体 DNA 拷贝数（mtDNAcn）与儿童期肥胖之间的关系：在纽约市多米尼加和非裔美国儿童的前瞻性出生队列（1998-2006 年）中，对脐带血中的 mtDNAcn 进行了测量。儿童（N = 336）在 5、7、9 和 11 岁时接受了身高、体重和生物阻抗评估。我们使用线性混合效应模型来评估脐带血中的 mtDNAcn tertiles 与儿童体重指数、体重指数 z 分数、脂肪质量指数和体脂百分比之间的关系。潜类生长模型以及mtDNAcn与儿童年龄或儿童年龄2之间的交互作用被用来评估年龄与肥胖轨迹之间的关系：与中mtDNAcn三分位数相比，低mtDNAcn三分位数个体的BMI平均高出1.5 kg/m2（95% CI：0.58，2.5）。体重指数 z 值、脂肪质量指数和体脂百分比的结果相似。此外，低mtDNAcn组的儿童处于 "增加 "或 "高稳定 "肥胖等级的几率增加：结论：出生时较低的线粒体DNAcn可能预示着儿童期较高的肥胖率，凸显了围产期线粒体功能在发育过程中对肥胖的潜在关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.