Intravenous hypertonic fluids as a source of human microplastic exposure

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-03-05 DOI:10.1016/j.etap.2024.104411

Uğur Çağlayan , Sedat Gündoğdu , Tiffany M. Ramos , Kristian Syberg

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引用次数: 0

Abstract

This study investigates the presence of microplastics (MPs) in hypertonic fluid solutions, a widely used medical treatment packaged predominantly in plastic. For this purpose, in this study, 13 hypertonic fluid samples from different brands and two different types of packaging (polypropylene and polyvinyl chloride) were analyzed using visual particle counting, µ-Raman microscopy and ATR-FTIR. The results reveal the pervasive presence of MPs in all samples, with an estimated average concentration of 62.82 ± 72.38 MPs/1000 mL. There was no statistically significant difference in MP concentration between PP and PVC packaging. The particles predominantly consisted of fragments (74.1%) and fibers (25.9%), ranging in size from 0.04 to 2.37 mm. µ-Raman analysis identified 12 synthetic polymers as well as cellulose, with polyethylene and cellulose being the most prevalent.

In conclusion, this study underscores the alarming presence of MPs in hypertonic fluid solutions, raising concerns about potential health risks.

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静脉注射高渗液体是人类接触微塑料的来源。

本研究调查了高渗溶液中微塑料（MPs）的存在情况，高渗溶液是一种广泛使用的医疗用品，主要采用塑料包装。为此，研究人员采用目视颗粒计数法、µ-拉曼显微镜法和 ATR-FTIR 法对 13 种不同品牌的高渗液样品进行了分析。结果显示，所有样品中都普遍存在 MPs，估计平均浓度为 62.82 ± 72.38 MPs/1000mL。溶液的包装材料为聚丙烯（PP）和聚氯乙烯（PVC）。有趣的是，聚丙烯（PP）和聚氯乙烯（PVC）包装的 MP 浓度在统计学上没有显著差异。颗粒主要由碎片（74.1%）和纤维（25.9%）组成，大小从 0.04 毫米到 2.37 毫米不等。µ-Raman 分析确定了 12 种合成聚合物和纤维素，其中聚乙烯和纤维素最为普遍。总之，这项研究强调了高渗液体溶液中存在令人担忧的 MPs，引起了人们对潜在健康风险的关注。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.