RESOLUTION OF CALVARIAL HYPEROSTOSIS IN AFRICAN LION CUBS (PANTHERA LEO LEO) AFTER VITAMIN A SUPPLEMENTATION.

IF 0.7 4区 农林科学 Q3 VETERINARY SCIENCES
Johannes S Siedenburg, Stefanie I Weiß, Viktor Molnár, Julia Tünsmeier, Merav Shamir, Veronika M Stein, Andrea Tipold
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Abstract

Two female (FL 1, FL 2) and one male (ML) 11-wk-old, intact, captive African lion cubs (Panthera leo leo) were presented with a history of mild vestibular signs. Initial serum vitamin A concentrations were low (140 nmol/L) for ML. Calvarial hyperostosis was confirmed using computed tomography (CT) of the head and cervical vertebrae in each cub. CT measurements were adapted in relation to the skull width. ML showed the most pronounced thickening of the tentorium cerebelli and occipital bone, represented by a tentorium cerebelli to skull width ratio (TCR) of 0.08 (FL 1: 0.06, FL 2: 0.05) and a basisphenoid to skull width ratio (BBR) of 0.07 (FL 1: 0.06, FL 2: 0.04). Magnetic resonance imaging (MRI) revealed cerebellar herniation and cervical intramedullary T2-weighted hyperintensity from C1, extending caudally for at least two cervical vertebrae in all cubs. Treatment was initiated with subcutaneous vitamin A supplementation and feeding of whole carcasses. Improvement in ataxia was noticed 3 wk later. Follow-up CT and MRI examinations were performed in ML after 3 and 8 mon. The affected bones appeared slightly less thickened and TCR and BBR had decreased to 0.05 after 3 mon. The cerebellum remained mildly herniated, accompanied by amelioration of cervical T2w hyperintensities. After 8 mon, evaluation and diagnostic imaging revealed further improvement regarding the neurologic status and measurements (TCR 0.05, BBR 0.04) despite persistence of a subtle cerebellar herniation. In conclusion, bone remodeling and improvement in clinical signs may be achievable in young lion cubs presented with calvarial hyperostosis and may be attributable to high-dose vitamin A supplementation.

补充维生素 A 后非洲幼狮(panthera leo leo)钙质骨质疏松症的缓解。
两只雌性幼狮(FL 1 和 FL 2)和一只雄性幼狮(ML)均为 11 周大的完整圈养非洲幼狮(Panthera leo leo),曾出现过轻微的前庭症状。ML 最初的血清维生素 A 浓度较低(140 nmol/L)。通过对每只幼熊的头部和颈椎进行计算机断层扫描(CT),确认了钙质骨质疏松症。CT 测量结果与头骨宽度相适应。ML表现为大脑触角和枕骨最明显的增厚,大脑触角与头骨宽度比(TCR)为0.08(FL 1:0.06,FL 2:0.05),蝶骨基础与头骨宽度比(BBR)为0.07(FL 1:0.06,FL 2:0.04)。磁共振成像(MRI)显示小脑疝和颈椎髓内 T2 加权高密度,从 C1 开始,所有幼熊都至少有两节颈椎向尾部延伸。治疗开始时,幼熊皮下注射维生素 A,并喂食整块胴体。3 周后,共济失调症状有所改善。3 个月和 8 个月后,对 ML 进行了 CT 和 MRI 随访检查。3 个月后,受影响骨骼的增厚程度略有减轻,TCR 和 BBR 已降至 0.05。小脑仍有轻度疝,颈椎 T2w 高密度有所改善。8 个月后,评估和诊断成像显示神经系统状况和测量结果进一步改善(TCR 0.05,BBR 0.04),尽管小脑仍有轻微疝出。总之,对于患有腓骨骨质增生症的幼狮来说,骨骼重塑和临床症状的改善是可以实现的,这可能归功于大剂量维生素 A 的补充。
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来源期刊
Journal of Zoo and Wildlife Medicine
Journal of Zoo and Wildlife Medicine 农林科学-兽医学
CiteScore
1.70
自引率
14.30%
发文量
74
审稿时长
9-24 weeks
期刊介绍: The Journal of Zoo and Wildlife Medicine (JZWM) is considered one of the major sources of information on the biology and veterinary aspects in the field. It stems from the founding premise of AAZV to share zoo animal medicine experiences. The Journal evolved from the long history of members producing case reports and the increased publication of free-ranging wildlife papers. The Journal accepts manuscripts of original research findings, case reports in the field of veterinary medicine dealing with captive and free-ranging wild animals, brief communications regarding clinical or research observations that may warrant publication. It also publishes and encourages submission of relevant editorials, reviews, special reports, clinical challenges, abstracts of selected articles and book reviews. The Journal is published quarterly, is peer reviewed, is indexed by the major abstracting services, and is international in scope and distribution. Areas of interest include clinical medicine, surgery, anatomy, radiology, physiology, reproduction, nutrition, parasitology, microbiology, immunology, pathology (including infectious diseases and clinical pathology), toxicology, pharmacology, and epidemiology.
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