FIRST DETECTION OF CLINICAL DISEASE DUE TO ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 7A IN TWO AFRICAN ELEPHANTS (LOXODONTA AFRICANA) IN HUMAN CARE.

IF 0.7 4区农林科学 Q3 VETERINARY SCIENCES

Journal of Zoo and Wildlife Medicine Pub Date : 2024-03-01 DOI:10.1638/2023-0034

Melissa A Fayette, David J Minich, Hannah Sylvester, Erin Latimer

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引用次数: 0

Abstract

Multiple species of elephant endotheliotropic herpesvirus (EEHV) have caused fatal hemorrhagic disease in African (Loxodonta africana) and Asian (Elephas maximus) elephants. To date, EEHV7 has been detected only in benign pulmonary and skin nodules and in saliva of African elephants and has not been associated with clinical illness. Low-level viremia due to EEHV7A was detected via qPCR in two subadult African elephants during routine surveillance. Hematologic changes were noted in both elephants, including leukopenia, lymphopenia, monocytopenia, and band heterophilia. Treatment was initiated with famciclovir, antimicrobials, and rectal fluids, and one elephant received plasma transfusions due to a progressive decrease in platelet count. Both elephants remained asymptomatic throughout the viremias, with rapid resolution of hematologic abnormalities. These cases add to the current understanding of the epidemiology of EEHV in African elephants; to the authors' knowledge, they represent the first documentation of clinical disease due to EEHV7 infection in any elephant.

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首次在两头接受人类照料的非洲象（loxodonta africana）身上发现大象内皮细胞疱疹病毒 7a 导致的临床疾病。

多种大象内皮细胞疱疹病毒（EEHV）曾在非洲象（Loxodonta africana）和亚洲象（Elephas maximus）中引起致命的出血性疾病。迄今为止，EEHV7 只在非洲象的良性肺部和皮肤结节以及唾液中被检测到，而且与临床疾病无关。在例行监测期间，通过 qPCR 在两头亚成年非洲象体内检测到了 EEHV7A 导致的低水平病毒血症。两头大象都出现了血液学变化，包括白细胞减少、淋巴细胞减少、单核细胞减少和带状嗜异性。由于血小板数量逐渐减少，其中一头大象接受了血浆输注。两头大象在整个病毒血症期间均无症状，血液学异常也迅速缓解。这些病例加深了目前人们对非洲象EEHV流行病学的了解；据作者所知，这些病例是首次记录任何大象因感染EEHV7而导致临床疾病的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Zoo and Wildlife Medicine 农林科学-兽医学

CiteScore

1.70

自引率

14.30%

发文量

审稿时长

9-24 weeks

期刊介绍： The Journal of Zoo and Wildlife Medicine (JZWM) is considered one of the major sources of information on the biology and veterinary aspects in the field. It stems from the founding premise of AAZV to share zoo animal medicine experiences. The Journal evolved from the long history of members producing case reports and the increased publication of free-ranging wildlife papers. The Journal accepts manuscripts of original research findings, case reports in the field of veterinary medicine dealing with captive and free-ranging wild animals, brief communications regarding clinical or research observations that may warrant publication. It also publishes and encourages submission of relevant editorials, reviews, special reports, clinical challenges, abstracts of selected articles and book reviews. The Journal is published quarterly, is peer reviewed, is indexed by the major abstracting services, and is international in scope and distribution. Areas of interest include clinical medicine, surgery, anatomy, radiology, physiology, reproduction, nutrition, parasitology, microbiology, immunology, pathology (including infectious diseases and clinical pathology), toxicology, pharmacology, and epidemiology.