Enhancing cardiometabolic health: unveiling the synergistic effects of high-intensity interval training with spirulina supplementation on selected adipokines, insulin resistance, and anthropometric indices in obese males

IF 3.9 2区医学 Q2 NUTRITION & DIETETICS

Nutrition & Metabolism Pub Date : 2024-03-07 DOI:10.1186/s12986-024-00785-0

Maryam Delfan, Ayoub Saeidi, Rashmi Supriya, Kurt A Escobar, Ismail Laher, Katie M. Heinrich, Katja Weiss, Beat Knechtle, Hassane Zouhal

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Abstract

This study investigated the combined effects of 12 weeks of high-intensity interval training (HIIT) and spirulina supplementation on adipokine levels, insulin resistance, anthropometric indices, and cardiorespiratory fitness in 44 obese males (aged 25–40 years). The participants were randomly assigned to one of four groups: control (CG), supplement (SG), training (TG), or training plus supplement (TSG). The intervention involved daily administration of either spirulina or a placebo and HIIT three times a week for the training groups. Anthropometric indices, HOMA-IR, VO2peak, and circulating adipokines (asprosin and lipocalin2, omentin-1, irisin, and spexin) were measured before and after the 12-week intervention. Post-intervention analysis indicated differences between the CG and the three interventional groups for body weight, fat-free mass (FFM), percent body fat (%BF), HOMA-IR, and adipokine levels (p < 0.05). TG and SG participants had increased VO2peak (p < 0.05). Spirulina supplementation with HIIT increased VO2peak, omentin-1, irisin, and spexin, while causing decreases in lipocalin-2 and asprosin levels and improvements in body composition (weight, %fat), BMI, and HOMA-IR. Notably, the combination of spirulina and HIIT produced more significant changes in circulating adipokines and cardiometabolic health in obese males compared to either supplementation or HIIT alone (p < 0.05). These findings highlight the synergistic benefits of combining spirulina supplementation with HIIT, showcasing their potential in improving various health parameters and addressing obesity-related concerns in a comprehensive manner.

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增强心脏代谢健康：揭示高强度间歇训练与螺旋藻补充剂对肥胖男性特定脂肪因子、胰岛素抵抗和人体测量指数的协同效应

本研究调查了在 44 名肥胖男性（25-40 岁）中进行为期 12 周的高强度间歇训练（HIIT）和螺旋藻补充剂对脂肪因子水平、胰岛素抵抗、人体测量指数和心肺功能的综合影响。参与者被随机分配到四组中的一组：对照组（CG）、补充剂组（SG）、训练组（TG）或训练加补充剂组（TSG）。干预措施包括每天服用螺旋藻或安慰剂，训练组每周进行三次 HIIT 训练。在为期 12 周的干预前后，对人体测量指数、HOMA-IR、VO2 峰值和循环脂肪因子（asprosin 和 lipocalin2、ommentin-1、irisin 和 spexin）进行了测量。干预后的分析表明，CG 组和三个干预组在体重、无脂肪量（FFM）、体脂百分比（%BF）、HOMA-IR 和脂肪因子水平方面存在差异（P < 0.05）。TG和SG参与者的VO2峰值有所提高（P < 0.05）。在补充螺旋藻的同时进行 HIIT 可提高 VO2 峰、网膜素-1、鸢尾素和沙棘素水平，同时降低脂钙素-2 和天冬氨酸水平，改善身体成分（体重、脂肪百分比）、体重指数和 HOMA-IR。值得注意的是，与单独补充螺旋藻或进行 HIIT 相比，螺旋藻与 HIIT 的结合对肥胖男性的循环脂肪因子和心脏代谢健康产生了更显著的变化（p < 0.05）。这些研究结果凸显了螺旋藻补充剂与 HIIT 的协同作用，展示了它们在改善各种健康指标和全面解决肥胖相关问题方面的潜力。

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来源期刊

Nutrition & Metabolism 医学-营养学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.