Hepatitis C Virus Infection and Hospital-Related Outcomes: A Systematic Review

IF 2.7 4区 医学 Q2 Medicine
Michelle Ng, Patrizia Maria Carrieri, Lindila Awendila, Maria Eugenia Socías, Rod Knight, Lianping Ti
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Abstract

Background. People living with hepatitis C infection (HCV) have a significant impact on the global healthcare system, with high rates of inpatient service use. Direct-acting antivirals (DAAs) have the potential to alleviate this burden; however, the evidence on the impact of HCV infection and hospital outcomes is undetermined. This systematic review aims to assess this research gap, including how DAAs may modify the relationship between HCV infection and hospital-related outcomes. Methods. We searched five databases up to August 2022 to identify relevant studies evaluating the impact of HCV infection on hospital-related outcomes. We created an electronic database of potentially eligible articles, removed duplicates, and then independently screened titles, abstracts, and full-text articles. Results. A total of 57 studies were included. Analysis of the included studies found an association between HCV infection and increased number of hospitalizations, length of stay, and readmissions. There was less consistent evidence of a relationship between HCV and in-hospital mortality. Only four studies examined the impact of DAAs, which showed that DAAs were associated with a reduction in hospitalizations and mortality. In the 14 studies available among people living with HIV, HCV coinfection similarly increased hospitalization, but there was less evidence for the other hospital-related outcomes. Conclusions. There is good to high-quality evidence that HCV negatively impacts hospital-related outcomes, primarily through increased hospitalizations, length of stay, and readmissions. Given the paucity of studies on the effect of DAAs on hospital outcomes, future research is needed to understand their impact on hospital-related outcomes.
丙型肝炎病毒感染与医院相关结果:系统回顾
背景。丙型肝炎感染者(HCV)对全球医疗保健系统产生了重大影响,其住院服务使用率很高。直接作用抗病毒药物(DAAs)有可能减轻这一负担;然而,有关 HCV 感染和住院结果影响的证据尚未确定。本系统综述旨在评估这一研究空白,包括 DAAs 如何改变 HCV 感染与医院相关结果之间的关系。方法。我们检索了截至 2022 年 8 月的五个数据库,以确定评估 HCV 感染对医院相关预后影响的相关研究。我们创建了一个潜在合格文章的电子数据库,删除了重复的文章,然后独立筛选了标题、摘要和全文。结果。共纳入 57 项研究。对纳入研究的分析发现,HCV 感染与住院次数、住院时间和再入院率的增加存在关联。关于 HCV 与院内死亡率之间关系的证据不太一致。只有四项研究考察了 DAAs 的影响,结果表明 DAAs 与住院次数和死亡率的减少有关。在针对艾滋病病毒感染者的 14 项研究中,HCV 合并感染同样会增加住院率,但其他医院相关结果的证据较少。结论。有高质量的证据表明,HCV 对医院相关结果有负面影响,主要是通过增加住院次数、住院时间和再入院率。鉴于有关 DAAs 对医院预后影响的研究较少,未来需要开展研究以了解其对医院相关预后的影响。
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来源期刊
CiteScore
4.80
自引率
0.00%
发文量
0
审稿时长
37 weeks
期刊介绍: Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery. The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.
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