Changes in biomarkers levels from gingival crevicular fluid in pre- and postmenopausal women undergoing orthodontic treatment : A systematic review.

IF 1.3 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Deborah Ribeiro Frazão, Yago Gecy de Souza Né, Maria Karolina Martins Ferreira, Nathália Carolina Fernandes Fagundes, Guido Marañón-Vásquez, Lucianne Cople Maia, Matheus Melo Pithon, Rafael Rodrigues Lima
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引用次数: 0

Abstract

Purpose: This study aimed to verify whether there is a difference in biomarker levels in the gingival crevicular fluid between premenopausal and postmenopausal women undergoing orthodontic treatment.

Methods: As eligibility criteria, prospective or retrospective observational studies evaluating women undergoing orthodontic treatment (P), comparing postmenopausal (E) and premenopausal (C) women, and analyzing differences in gingival crevicular fluid biomarkers (O) were included. An electronic search was conducted in seven databases (PubMed, Scopus, Web of Science, LILACS, The Cochrane Library, Embase, and EBSCO: Dentistry & Oral Science) and one grey literature source (Google Scholar). All databases were searched from September 2022 to March 2023. After duplicate exclusion and data extraction, the Newcastle-Ottawa scale was applied to assess the quality and risk of bias, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool was used to verify the certainty of evidence.

Results: Three case-control studies that analyzed receptor activator of nuclear factor kappa‑B ligand (RANKL), osteopontin (OPN), and interleukin (IL)-17A levels were included. One study reported a significant difference for RANKL and another for OPN levels. A third study reported that there was a higher expression of IL17‑A in the postmenopausal group. However, the small number of articles limits our systematic review. The heterogeneity and imprecision in the study results cast doubt on the findings' internal validity.

Conclusion: The studies reported alterations in biomarker levels but differed in their conclusions. Therefore, further studies must include other types of bone and inflammatory biomarkers in female patients who are pre- or postmenopausal and undergoing orthodontic treatment.

Registration: The review was registered at the Open Science Framework ( https://doi.org/10.17605/OSF.IO/Q9YZ8 ).

Abstract Image

接受正畸治疗的绝经前后妇女牙龈缝隙液中生物标志物水平的变化 :系统综述。
目的:本研究旨在验证接受正畸治疗的绝经前和绝经后妇女牙龈缝隙液中的生物标志物水平是否存在差异:作为资格标准,纳入的前瞻性或回顾性观察研究均评估了接受正畸治疗的妇女(P),比较了绝经后妇女(E)和绝经前妇女(C),并分析了牙龈缝液生物标志物的差异(O)。在七个数据库(PubMed、Scopus、Web of Science、LILACS、The Cochrane Library、Embase 和 EBSCO)中进行了电子检索:Dentistry & Oral Science)和一个灰色文献来源(Google Scholar)。所有数据库的检索时间为 2022 年 9 月至 2023 年 3 月。重复排除和数据提取后,采用纽卡斯尔-渥太华量表评估质量和偏倚风险,并使用建议评估、发展和评价分级(GRADE)工具验证证据的确定性:结果:纳入了三项病例对照研究,这些研究分析了核因子卡巴-B配体受体激活剂(RANKL)、骨生成素(OPN)和白细胞介素(IL)-17A的水平。一项研究报告称,RANKL 和 OPN 水平存在显著差异。第三项研究报告称,绝经后组中 IL17-A 的表达较高。然而,文章数量少限制了我们的系统综述。研究结果的异质性和不精确性使人对研究结果的内部有效性产生怀疑:这些研究报告了生物标志物水平的变化,但得出的结论各不相同。因此,进一步的研究必须包括绝经前或绝经后接受正畸治疗的女性患者的其他类型的骨和炎症生物标志物:该综述已在开放科学框架 ( https://doi.org/10.17605/OSF.IO/Q9YZ8 ) 注册。
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
64
审稿时长
>12 weeks
期刊介绍: The Journal of Orofacial Orthopedics provides orthodontists and dentists who are also actively interested in orthodontics, whether in university clinics or private practice, with highly authoritative and up-to-date information based on experimental and clinical research. The journal is one of the leading publications for the promulgation of the results of original work both in the areas of scientific and clinical orthodontics and related areas. All articles undergo peer review before publication. The German Society of Orthodontics (DGKFO) also publishes in the journal important communications, statements and announcements.
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