Impact of the neutrophil-to-lymphocyte ratio on patients with locally advanced non-small cell lung cancer who suffer radiation pneumonitis during the course of induction chemoradiotherapy followed by surgery.

IF 1.7 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2024-09-01 Epub Date: 2024-03-07 DOI:10.1007/s00595-024-02816-y

Yujiro Kubo, Hiromasa Yamamoto, Kei Matsubara, Kohei Hashimoto, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Kuniaki Katsui, Takao Hiraki, Katsuyuki Kiura, Shinichi Toyooka

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引用次数: 0

Abstract

Purpose: Radiation pneumonitis (RP) is an obstacle for patients after surgery following induction chemoradiotherapy for locally advanced non-small cell lung cancer (LA-NSCLC). We performed a comparative analysis of the association between clinicopathological factors, including the neutrophil-to-lymphocyte ratio (NLR) and prognosis, in LA-NSCLC patients with or without RP during induction chemoradiotherapy followed by surgery.

Methods: The subjects of this analysis were 168 patients undergoing trimodality therapy for LA-NSCLC between January, 1999 and May, 2019. Patients were divided into two groups: the RP group (n = 41) and the non-RP group (n = 127). We compared the clinicopathological factors including the NLR between the groups and analyzed the association between the NLR and prognosis.

Results: The RP group had more patients with tumors located in the lower lobe, more bilobar resections, shorter operative times, no implementation of postoperative adjuvant chemotherapy, and a higher postoperative NLR than the non-RP group. There were no significant differences in serious postoperative complications and the prognosis. Patients with a low postoperative NLR had a significantly better prognosis in the non-RP group, and a trend toward a better prognosis even in the RP group.

Conclusion: Postoperative NLR may be a useful prognostic factor, even for patients who suffer RP after trimodality therapy for LA-NSCLC.

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局部晚期非小细胞肺癌患者在接受诱导化放疗和手术治疗期间出现放射性肺炎时，中性粒细胞与淋巴细胞比值对患者的影响。

目的：放射性肺炎（RP）是局部晚期非小细胞肺癌（LA-NSCLC）诱导化放疗术后患者术后的一个障碍。我们对在诱导化疗后接受手术治疗的 LA-NSCLC 患者有无 RP 的临床病理因素（包括中性粒细胞与淋巴细胞比值（NLR））与预后之间的关系进行了比较分析：分析对象为1999年1月至2019年5月期间接受三联疗法治疗的168名LA-NSCLC患者。患者分为两组：RP组（41人）和非RP组（127人）。我们比较了两组患者的临床病理因素，包括NLR，并分析了NLR与预后之间的关联：结果：与非RP组相比，RP组肿瘤位于下叶的患者更多，双叶切除术更多，手术时间更短，术后未实施辅助化疗，术后NLR更高。术后严重并发症和预后无明显差异。术后NLR较低的患者在非RP组中预后明显较好，甚至在RP组中也有预后较好的趋势：结论：术后NLR可能是一个有用的预后因素，即使对于LA-NSCLC三模式治疗后出现RP的患者也是如此。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.