Whole-genome doubling is a double-edged sword: the heterogeneous role of whole-genome doubling in various cancer types.

IF 2.9 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

BMB Reports Pub Date : 2024-03-01

Eunhyong Chang, Joon-Yong An

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引用次数: 0

Abstract

Whole-genome doubling (WGD), characterized by the duplication of an entire set of chromosomes, is commonly observed in various tumors, occurring in approximately 30-40% of patients with different cancer types. The effect of WGD on tumorigenesis varies depending on the context, either promoting or suppressing tumor progression. Recent advances in genomic technologies and large-scale clinical investigations have led to the identification of the complex patterns of genomic alterations underlying WGD and their functional consequences on tumorigenesis progression and prognosis. Our comprehensive review aims to summarize the causes and effects of WGD on tumorigenesis, highlighting its dualistic influence on cancer cells. We then introduce recent findings on WGD-associated molecular signatures and genetic aberrations and a novel subtype related to WGD. Finally, we discuss the clinical implications of WGD in cancer subtype classification and future therapeutic interventions. Overall, a comprehensive understanding of WGD in cancer biology is crucial to unraveling its complex role in tumorigenesis and identifying novel therapeutic strategies. [BMB Reports 2024; 57(3): 125-134].

本刊更多论文

全基因组加倍是一把双刃剑：全基因组加倍在不同癌症类型中的异质性作用。

全基因组加倍（WGD）的特点是整组染色体的重复，在各种肿瘤中都能观察到，不同癌症类型的患者中约有 30%-40% 会出现这种情况。WGD 对肿瘤发生的影响因情况而异，有的会促进肿瘤进展，有的则会抑制肿瘤进展。基因组学技术和大规模临床研究的最新进展促使人们确定了 WGD 潜在的复杂基因组改变模式及其对肿瘤发生、发展和预后的功能性影响。我们的综合综述旨在总结 WGD 对肿瘤发生的原因和影响，强调其对癌细胞的双重影响。然后，我们介绍了与 WGD 相关的分子特征和遗传畸变的最新发现，以及与 WGD 相关的一种新型亚型。最后，我们讨论了 WGD 对癌症亚型分类和未来治疗干预的临床意义。总之，全面了解癌症生物学中的 WGD 对于揭示其在肿瘤发生中的复杂作用和确定新型治疗策略至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMB Reports 生物-生化与分子生物学

CiteScore

5.10

自引率

7.90%

发文量

141

审稿时长

1 months

期刊介绍： The BMB Reports (BMB Rep, established in 1968) is published at the end of every month by Korean Society for Biochemistry and Molecular Biology. Copyright is reserved by the Society. The journal publishes short articles and mini reviews. We expect that the BMB Reports will deliver the new scientific findings and knowledge to our readers in fast and timely manner.