Evaluating the effects of Bacopa monnieri on cognitive performance and sleep quality of patients with mild cognitive impairment: A triple-blinded, randomized, placebo-controlled trial

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-03 DOI:10.1016/j.explore.2024.02.008

Maryam Delfan , Parastou Kordestani-Moghaddam , Mohammad Gholami , Khadije Kazemi , Rasool Mohammadi

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Abstract

Introduction

Mild cognitive impairment is the middle level of natural cognitive impairment during primary steps of dementia. There are a few studies about improving the cognitive performance and sleep quality in patients with a limited dementia. So, this study was conducted to evaluate the effects of Bacopa monnieri on cognitive performance and sleep quality of patients with mild cognitive impairment.

Materials and methods

In this study, 62 patients with mild cognitive impairment were categorized into two groups of control and intervention. The intervention group received one pill of 160 mg Bacopa monnieri extract in 2 months, and the control group received a pill containing starch powder. The cognitive impairment and sleep quality was assessed using a questionnaire containing demographic information, Montreal Cognitive Assessment, and the Pittsburg Sleep Quality Index in three time-points of before the study, one months after the intervention and 2 months after the intervention (the end of study).

Results

The results showed no statistically significant difference between two groups in all three time-points in overall cognitive performance score and its 6 parameters (P > 0.05). While in the field of attention at the end of the first month (P = 0.033) and the end of the second month (P = 0.004), it was significant difference between the study groups. Also, in the field of verbal fluency at the end of the second month, this difference was significant (P = 0.003). The cognitive performance overall score showed no significant difference between two groups in first (P = 0.939) and second time-points (P = 0.661), although it was significant at third time-point (P = 0.029). There was no statistically significant difference between two groups in all time-points for sleep quality overall score (P > 0.05).

Conclusion

The results showed that Bacopa monnieri can improve the cognitive performance overall score and some of its parameters, but it had no effect on sleep quality.

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评估巴戟天对轻度认知障碍患者认知能力和睡眠质量的影响：三盲临床试验

轻度认知障碍是痴呆症初级阶段自然认知障碍的中间水平。关于改善轻度痴呆患者认知能力和睡眠质量的研究很少。因此，本研究旨在评估对轻度认知障碍患者的认知能力和睡眠质量的影响。在这项研究中，62 名轻度认知障碍患者被分为对照组和干预组两组。干预组在两个月内服用一次160毫克提取物的药片，对照组服用含淀粉粉末的药片。在研究前、干预后一个月和干预后两个月（研究结束）三个时间点，使用包含人口统计学信息、蒙特利尔认知评估和匹兹堡睡眠质量指数的问卷对认知障碍和睡眠质量进行了评估。结果表明，在所有三个时间点上，两组在认知能力总分及其 6 个参数上的差异均无统计学意义（P>0.05）。而在注意力方面，研究组在第一个月末（P=0.033）和第二个月末（P=0.004）有显著差异。此外，在第二个月末，语言流畅性方面的差异也很明显（P=0.003）。认知表现总分在第一个时间点（P=0.939）和第二个时间点（P=0.661）两组间无显著差异，但在第三个时间点有显著差异（P=0.029）。两组在所有时间点的睡眠质量总分差异均无统计学意义（P>0.05）。结果表明，认知能力总分及其部分参数可以改善，但对睡眠质量没有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.