Musculoskeletal symptoms and their impact on health-related quality of life in chronic nonbacterial osteomyelitis patients

IF 2.8 3区医学 Q1 PEDIATRICS

Pediatric Rheumatology Pub Date : 2024-03-06 DOI:10.1186/s12969-024-00971-7

Samar Tharwat, Mohammed Kamal Nassar

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引用次数: 0

Abstract

Chronic non-bacterial osteomyelitis (CNO) is a rare, non-infection- related inflammatory disorder that affects children and teens. Clinical manifestations of CNO range widely from moderate, time-limited, monofocal inflammation of the bone to extreme multifocal or chronically active inflammation of the bone. The main aim of this study was to explore the correlation between musculoskeletal (MSK) symptoms and health-related quality of life (HRQoL) in patients with CNO. Children and adults with CNO and their parents were asked to answer a web-based survey. The survey consisted of multiple questions centered around demographic, clinical and therapeutic data, MSK discomfort form based on the Nordic MSK Questionnaire and HRQoL based on Pediatric Quality of Life Inventory-4 (PedsQL-4) and PedsQL rheumatology module. The inclusion criteria included diagnosis of CNO before the age of 18. Patients who had malignancies or any chronic rheumatic, MSK, neurological disease prior to CNO onset were excluded. There was a total of 68 participants, mostly females (66.2%), with median age 14 years and median disease duration 4.75 years. The median number of bones affected by CNO was 5 and ranged from 1 to 24 bones. Among the studied patients, 45 patients (66.2%) had MSK manifestations at the last month. The most commonly affected part was ankle and feet (26.5%). Regarding HRQoL, patients with MSK manifestations had lower scores than did patients without in PedsQL-4 (p < 0.001) including domains of physical functioning (p < 0.001), emotional functioning (p = 0.033), social functioning (p < 0.001) and school functioning (p = 0.007) in addition to lower scores in PedsQL rheumatology module (p < 0.001) including domains of pain and hurt (p < 0.001), daily activities (p < 0.001), treatment (p = 0.035), worry (p = 0.001) and communication (p < 0.001). MSK manifestations have a negative impact on HRQoL in CNO patients. So, early identification and treatment are highly recommended.

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慢性非细菌性骨髓炎患者的肌肉骨骼症状及其对健康相关生活质量的影响

慢性非细菌性骨髓炎（CNO）是一种罕见的非感染性炎症性疾病，多发于儿童和青少年。慢性非细菌性骨髓炎的临床表现多种多样，既有中度、有时间限制的单灶性骨炎，也有极端的多灶性或慢性活动性骨炎。本研究的主要目的是探讨 CNO 患者的肌肉骨骼（MSK）症状与健康相关生活质量（HRQoL）之间的相关性。研究人员要求患有 CNO 的儿童和成人及其父母回答一项网络调查。调查由多个问题组成，主要涉及人口统计学、临床和治疗数据、基于北欧 MSK 问卷的 MSK 不适症状表以及基于儿科生活质量量表-4 (PedsQL-4) 和 PedsQL 风湿模块的 HRQoL。纳入标准包括 18 岁前诊断为 CNO 的患者。排除在 CNO 发病前患有恶性肿瘤或任何慢性风湿病、多发性硬化症、神经系统疾病的患者。共有 68 名参与者，大部分为女性（66.2%），年龄中位数为 14 岁，病程中位数为 4.75 年。受 CNO 影响的骨头数量中位数为 5 根，从 1 根到 24 根不等。在所研究的患者中，有45名患者（66.2%）在最近一个月出现过MSK表现。最常受影响的部位是踝关节和足部（26.5%）。在 HRQoL 方面，有 MSK 表现的患者在 PedsQL-4 中的得分低于无 MSK 表现的患者（p < 0.001），包括身体功能（p < 0.001）、情绪功能（p = 0.033）、社会功能（p < 0.001）、社会功能（p = 0.033）和学校功能（p = 0.007），此外，PedsQL风湿模块（p < 0.001），包括疼痛和伤害（p < 0.001）、日常活动（p < 0.001）、治疗（p = 0.035）、担忧（p = 0.001）和沟通（p < 0.001）的得分也较低。MSK 表现对 CNO 患者的 HRQoL 有负面影响。因此，强烈建议及早识别和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Rheumatology PEDIATRICS-RHEUMATOLOGY

CiteScore

4.10

自引率

8.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pediatric Rheumatology is an open access, peer-reviewed, online journal encompassing all aspects of clinical and basic research related to pediatric rheumatology and allied subjects. The journal’s scope of diseases and syndromes include musculoskeletal pain syndromes, rheumatic fever and post-streptococcal syndromes, juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis, local and systemic scleroderma, Kawasaki disease, Henoch-Schonlein purpura and other vasculitides, sarcoidosis, inherited musculoskeletal syndromes, autoinflammatory syndromes, and others.