Iso-osmolar vs low-osmolar contrast agents for coronary optical coherence tomography: a blinded prospective randomized controlled study.

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Invasive Cardiology Pub Date : 2024-06-01 DOI:10.25270/jic/23.00136

Spyridon Kostantinis, Olga Mastrodemos, Larissa Stanberry, Yader Sandoval, Salman S Allana, Deniz Mutlu, Bahadir Simsek, Athanasios Rempakos, Judit Karacsonyi, Michaella Alexandrou, Brynn K Okeson, M Nicholas Burke, Bavana V Rangan, Emmanouil S Brilakis

{"title":"Iso-osmolar vs low-osmolar contrast agents for coronary optical coherence tomography: a blinded prospective randomized controlled study.","authors":"Spyridon Kostantinis, Olga Mastrodemos, Larissa Stanberry, Yader Sandoval, Salman S Allana, Deniz Mutlu, Bahadir Simsek, Athanasios Rempakos, Judit Karacsonyi, Michaella Alexandrou, Brynn K Okeson, M Nicholas Burke, Bavana V Rangan, Emmanouil S Brilakis","doi":"10.25270/jic/23.00136","DOIUrl":null,"url":null,"abstract":"Background: The impact of contrast type on coronary optical coherence tomography (OCT) imaging has received limited research.Methods: We conducted a blinded, prospective, single-center, randomized, controlled crossover study comparing iso-osmolar contrast media (IOCM) with low-osmolar contrast media (LOCM) in patients undergoing clinically indicated coronary OCT imaging. Patients were randomly assigned to undergo OCT imaging with either IOCM or LOCM as the initial contrast medium. Following a washout period, a second run of OCT imaging of the same coronary vessel was performed using the other contrast medium.Results: A total of 62 patients were randomized to IOCM first (n = 31) or LOCM first (n = 31). Mean patient age was 65.9 ± 11.2 years and 74.2% were male, with high prevalence of dyslipidemia (82.3%) and prior myocardial infarction (41.9%). Percutaneous coronary intervention was performed in 60 cases (96.8%) and the left anterior descending artery was the most common target vessel (53.3%). The contrast volume used for OCT imaging was similar for IOCM and LOCM (8.0 [6.9, 9.0] mL vs 8.0 [6.7, 9.0] mL; P = .89), as was the length of clear OCT images (70.0 [62.8, 74.0] mm for IOCM vs 70.0 [64.0, 74.0] mm for LOCM; P = .65). Electrocardiographic changes were observed in 11 runs with IOCM (ventricular repolarization changes in 9 runs and premature ventricular contractions [PVCs] in 2 runs) vs 12 runs with LOCM (ventricular repolarization changes in 9 runs and PVCs in 3 runs).Conclusions: The use of IOCM in coronary OCT is associated with similar contrast volume and clear imaging length when compared with LOCM.","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Invasive Cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.25270/jic/23.00136","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The impact of contrast type on coronary optical coherence tomography (OCT) imaging has received limited research.

Methods: We conducted a blinded, prospective, single-center, randomized, controlled crossover study comparing iso-osmolar contrast media (IOCM) with low-osmolar contrast media (LOCM) in patients undergoing clinically indicated coronary OCT imaging. Patients were randomly assigned to undergo OCT imaging with either IOCM or LOCM as the initial contrast medium. Following a washout period, a second run of OCT imaging of the same coronary vessel was performed using the other contrast medium.

Results: A total of 62 patients were randomized to IOCM first (n = 31) or LOCM first (n = 31). Mean patient age was 65.9 ± 11.2 years and 74.2% were male, with high prevalence of dyslipidemia (82.3%) and prior myocardial infarction (41.9%). Percutaneous coronary intervention was performed in 60 cases (96.8%) and the left anterior descending artery was the most common target vessel (53.3%). The contrast volume used for OCT imaging was similar for IOCM and LOCM (8.0 [6.9, 9.0] mL vs 8.0 [6.7, 9.0] mL; P = .89), as was the length of clear OCT images (70.0 [62.8, 74.0] mm for IOCM vs 70.0 [64.0, 74.0] mm for LOCM; P = .65). Electrocardiographic changes were observed in 11 runs with IOCM (ventricular repolarization changes in 9 runs and premature ventricular contractions [PVCs] in 2 runs) vs 12 runs with LOCM (ventricular repolarization changes in 9 runs and PVCs in 3 runs).

Conclusions: The use of IOCM in coronary OCT is associated with similar contrast volume and clear imaging length when compared with LOCM.

查看原文本刊更多论文

用于冠状动脉光学相干断层扫描的等渗透性造影剂与低渗透性造影剂：一项盲法前瞻性随机对照研究。

背景：对比剂类型对冠状动脉光学相干断层成像（OCT）的影响研究有限：对比剂类型对冠状动脉光学相干断层扫描（OCT）成像的影响研究有限：我们进行了一项盲法、前瞻性、单中心、随机对照交叉研究，比较了等渗透性造影剂（IOCM）和低渗透性造影剂（LOCM）对临床冠状动脉 OCT 成像的影响。患者被随机分配接受以 IOCM 或 LOCM 作为初始造影剂的 OCT 成像。经过一段时间的冲洗后，使用另一种造影剂对同一冠状动脉血管进行第二次 OCT 成像：共有 62 名患者被随机分配到先进行 IOCM（31 人）或先进行 LOCM（31 人）。患者平均年龄为 65.9 ± 11.2 岁，74.2% 为男性，血脂异常（82.3%）和既往心肌梗死（41.9%）发病率较高。60例患者（96.8%）接受了经皮冠状动脉介入治疗，左前降支动脉是最常见的靶血管（53.3%）。IOCM 和 LOCM 的 OCT 成像使用的造影剂量相似（8.0 [6.9, 9.0] mL vs 8.0 [6.7, 9.0] mL；P = .89），清晰 OCT 图像的长度也相似（IOCM 为 70.0 [62.8, 74.0] mm vs LOCM 为 70.0 [64.0, 74.0] mm；P = .65）。在使用 IOCM 的 11 次运行中观察到心电图变化（9 次运行中观察到心室复极化变化，2 次运行中观察到室性早搏 [PVC]），而在使用 LOCM 的 12 次运行中观察到心电图变化（9 次运行中观察到心室复极化变化，3 次运行中观察到室性早搏 [PVC]）：结论：与 LOCM 相比，在冠状动脉 OCT 中使用 IOCM 可获得相似的对比度和清晰的成像长度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Invasive Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.90

自引率

6.70%

发文量

214

审稿时长

3-8 weeks

期刊介绍： The Journal of Invasive Cardiology will consider for publication suitable articles on topics pertaining to the invasive treatment of patients with cardiovascular disease.