{"title":"Bacterial cellulose as an ideal potential treatment for burn wounds: A comprehensive review.","authors":"Farzaneh Jabbari, Valiollah Babaeipour","doi":"10.1111/wrr.13163","DOIUrl":null,"url":null,"abstract":"<p><p>Burn wound regeneration is a complex process, which has many serious challenges such as slow wound healing, secondary infection, and inflammation. Therefore, it is essential to utilise appropriate biomaterials to accelerate and guide the wound healing process. Bacterial cellulose (BC), a natural polymer synthesised by some bacteria, has attracted much attention for wound healing applications due to its unique properties including excellent physicochemical and mechanical properties, simple purification process, three-dimensional (3D) network structure similar to extracellular matrix, high purity, high water holding capacity and significant permeability to gas and liquid. BC's lack of antibacterial activity significantly limits its biomedical and tissue engineering application, but adding antimicrobial agents to it remarkably improves its performance in tissue regeneration applications. Burn wound healing is a complex long-lasting process. Using biomaterials in wound treatment has shown that they can satisfactorily accelerate wound healing. The purpose of this review is to elaborate on the importance of BC-based structures as one of the most widely used modern wound dressings in the treatment of burn wounds. In addition, the combination of various drugs, agents, cells and biomolecules with BC to expand its application in burn injury regeneration is discussed. Finally, the main challenges and future development direction of BC-based structures for burn wound repair are considered. The four most popular search engines PubMed/MEDLINE, Science Direct, Scopus and Google Scholar were used to help us find relevant papers. The most frequently used keywords were bacterial cellulose, BC-based biocomposite, wound healing, burn wound and vascular graft.</p>","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"323-339"},"PeriodicalIF":3.8000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Wound Repair and Regeneration","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/wrr.13163","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Burn wound regeneration is a complex process, which has many serious challenges such as slow wound healing, secondary infection, and inflammation. Therefore, it is essential to utilise appropriate biomaterials to accelerate and guide the wound healing process. Bacterial cellulose (BC), a natural polymer synthesised by some bacteria, has attracted much attention for wound healing applications due to its unique properties including excellent physicochemical and mechanical properties, simple purification process, three-dimensional (3D) network structure similar to extracellular matrix, high purity, high water holding capacity and significant permeability to gas and liquid. BC's lack of antibacterial activity significantly limits its biomedical and tissue engineering application, but adding antimicrobial agents to it remarkably improves its performance in tissue regeneration applications. Burn wound healing is a complex long-lasting process. Using biomaterials in wound treatment has shown that they can satisfactorily accelerate wound healing. The purpose of this review is to elaborate on the importance of BC-based structures as one of the most widely used modern wound dressings in the treatment of burn wounds. In addition, the combination of various drugs, agents, cells and biomolecules with BC to expand its application in burn injury regeneration is discussed. Finally, the main challenges and future development direction of BC-based structures for burn wound repair are considered. The four most popular search engines PubMed/MEDLINE, Science Direct, Scopus and Google Scholar were used to help us find relevant papers. The most frequently used keywords were bacterial cellulose, BC-based biocomposite, wound healing, burn wound and vascular graft.
烧伤伤口再生是一个复杂的过程,面临着许多严峻的挑战,如伤口愈合缓慢、继发感染和炎症。因此,利用适当的生物材料来加速和引导伤口愈合过程至关重要。细菌纤维素(BC)是一种由某些细菌合成的天然聚合物,由于其独特的性能,包括优异的物理化学和机械性能、简单的提纯过程、与细胞外基质相似的三维(3D)网络结构、高纯度、高持水性以及对气体和液体的显著渗透性,它在伤口愈合方面的应用已引起广泛关注。BC 缺乏抗菌活性,这大大限制了它在生物医学和组织工程方面的应用,但添加抗菌剂后,它在组织再生应用方面的性能明显提高。烧伤伤口愈合是一个复杂而持久的过程。在伤口治疗中使用生物材料表明,它们可以令人满意地加速伤口愈合。本综述旨在阐述以 BC 为基础的结构作为治疗烧伤创面最广泛应用的现代创面敷料之一的重要性。此外,还讨论了各种药物、制剂、细胞和生物大分子与 BC 的结合,以扩大其在烧伤再生中的应用。最后,探讨了基于 BC 的烧伤创面修复结构所面临的主要挑战和未来发展方向。我们使用了 PubMed/MEDLINE、Science Direct、Scopus 和 Google Scholar 四个最流行的搜索引擎来帮助我们查找相关论文。最常使用的关键词是细菌纤维素、BC 基生物复合材料、伤口愈合、烧伤创面和血管移植。
期刊介绍:
Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others.
Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.