Physical Exercise for Treating the Anxiety and Depression Symptoms of Parkinson's Disease: Systematic Review and Meta-Analysis.

IF 2.9 4区 医学 Q2 CLINICAL NEUROLOGY
Valton Costa, José Mario Prati, Alice de Oliveira Barreto Suassuna, Thanielle Souza Silva Brito, Thalita Frigo da Rocha, Anna Carolyna Gianlorenço
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引用次数: 0

Abstract

Background: Depression and anxiety are non-motor symptoms of Parkinson's disease (PD). Physical exercise is a promising approach to reducing neuropsychological burden. We aimed to comprehensively synthesize evidence regarding the use of exercise for treating depression and anxiety symptoms in PD.

Methods: Systematic review and meta-analysis following PRISMA recommendations. Searches on PubMed, Cochrane Library, Scopus, Web of Science, Embase, and Physiotherapy Evidence Database (PEDro) was conducted. The random-effects model was employed for all analyses with the standardized mean difference as the effect estimate.

Results: Fifty records were retrieved, but only 17 studies met the criteria for the meta-analyses. A moderate to large effect was observed for depression (-.71 [95% CI = -.96 to -.46], 11 studies, 728 individuals), and a small to moderate effect for anxiety (-.39 [95% CI = -.65 to -.14], 6 studies, 241 individuals), when comparing exercise to non-exercise controls. Subgroup analysis revealed significant effects from aerobic (-.95 [95% CI = -1.60, -.31]), mind-body (-1.85 [95% CI = -2.63, -1.07]), and resistance modalities (-1.61 [95% CI = -2.40, -.83]) for depression, and from mind-body (-.67 [95% CI = -1.19 to -.15]) and resistance exercises (-1.00 [95% CI = -1.70 to -.30]) for anxiety.

Conclusion: Physical exercise has a relevant clinical impact on depression and anxiety in PD. We discuss the level of the evidence, the methodological limitations of the studies, and give recommendations.

体育锻炼治疗帕金森病的焦虑和抑郁症状:系统回顾与元分析》。
背景:抑郁和焦虑是帕金森病(PD)的非运动症状:抑郁和焦虑是帕金森病(PD)的非运动症状。体育锻炼是减轻神经心理负担的有效方法。我们旨在全面综合有关使用运动治疗帕金森病抑郁和焦虑症状的证据:按照 PRISMA 建议进行系统回顾和荟萃分析。在PubMed、Cochrane Library、Scopus、Web of Science、Embase和物理治疗证据数据库(PEDro)上进行了检索。所有分析均采用随机效应模型,以标准化平均差作为效应估计值:结果:共检索到 50 条记录,但只有 17 项研究符合荟萃分析的标准。在将运动与非运动对照进行比较时,发现运动对抑郁症有中度至较大的影响(-.71 [95% CI = -.96 至 -.46] ,11 项研究,728 人),对焦虑症有小至中度的影响(-.39 [95% CI = -.65 至 -.14] ,6 项研究,241 人)。亚组分析显示,有氧运动(-.95 [95% CI = -1.60, -.31])、心身运动(-1.85 [95% CI = -2.63, -1.07])和阻力运动(-1.61 [95% CI = -2.40, -.83])对抑郁症有显著影响,心身运动(-.67 [95% CI = -1.19 to -.15])和阻力运动(-1.00 [95% CI = -1.70 to -.30])对焦虑症有显著影响:结论:体育锻炼对帕金森病患者的抑郁和焦虑有相关的临床影响。我们讨论了证据水平、研究方法的局限性,并给出了建议。
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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
40
审稿时长
>12 weeks
期刊介绍: Journal of Geriatric Psychiatry and Neurology (JGP) brings together original research, clinical reviews, and timely case reports on neuropsychiatric care of aging patients, including age-related biologic, neurologic, and psychiatric illnesses; psychosocial problems; forensic issues; and family care. The journal offers the latest peer-reviewed information on cognitive, mood, anxiety, addictive, and sleep disorders in older patients, as well as tested diagnostic tools and therapies.
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