Hypoglycemic effects of dracorhodin and dragon blood crude extract from Daemonorops draco.

IF 3.4 3区生物学 Q1 Agricultural and Biological Sciences

Botanical Studies Pub Date : 2024-03-06 DOI:10.1186/s40529-024-00415-1

Yung-Hao Ching, Fang-Mei Lin, Hong-Chi Chen, Ching-Yun Hsu, Sze Yen P'ng, Tai-No Lin, Yu-Chia Wang, Cheng-Jun Lin, Yi-Chi Chen, Tsung-Jung Ho, Hao-Ping Chen

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引用次数: 0

Abstract

Background: Dragon blood is a red fruit resin from the palm tree Daemonorops draco and is a herbal ingredient used in the traditional Chinese medicine, "Jinchuang Ointment," which is used to treat non-healing diabetic wounds. According to the Taiwan Herbal Pharmacopeia, the dracorhodin content in dragon blood should exceed 1.0%.

Results: Our findings indicate that dracorhodin and dragon blood crude extracts can stimulate glucose uptake in mouse muscle cells (C2C12) and primary rat aortic smooth muscle cells (RSMC). Dracorhodin is not the only active compound in dragon blood crude extracts from D. draco. Next, we orally administered crude dragon blood extracts to male B6 mice. The experimental group displayed a decreasing trend in fasting blood glucose levels from the second to tenth week. In summary, crude extracts of dragon blood from D. draco demonstrated in vivo hypoglycemic effects in B6 male mice.

Conclusions: We provide a scientific basis "Jinchuang ointment" in treating non-healing wounds in patients with diabetes.

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龙血素和龙血粗提取物的降血糖作用

背景：龙血是棕榈科植物龙血树的红色果实树脂，是传统中药 "金创膏 "中的一种中药成分，用于治疗糖尿病伤口不愈合。根据台湾《中药药典》的规定，龙血素的含量应超过 1.0%：我们的研究结果表明，龙血素和龙血粗提物可刺激小鼠肌肉细胞（C2C12）和原代大鼠主动脉平滑肌细胞（RSMC）的葡萄糖摄取。龙血树甙并不是龙血树粗提取物中唯一的活性化合物。接下来，我们给雄性 B6 小鼠口服龙血粗提物。从第二周到第十周，实验组的空腹血糖水平呈下降趋势。综上所述，龙血树龙血粗提物对雄性 B6 小鼠具有体内降血糖作用：我们为 "金创膏 "治疗糖尿病患者伤口不愈合提供了科学依据。

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来源期刊

Botanical Studies 生物-植物科学

CiteScore

5.50

自引率

2.90%

发文量

审稿时长

2.4 months

期刊介绍： Botanical Studies is an open access journal that encompasses all aspects of botany, including but not limited to taxonomy, morphology, development, genetics, evolution, reproduction, systematics, and biodiversity of all plant groups, algae, and fungi. The journal is affiliated with the Institute of Plant and Microbial Biology, Academia Sinica, Taiwan.