Investigation of the impact of liquid presence on the acoustic streaming generated by a vibrating sharp tip capillary

IF 2.3 4区 工程技术 Q2 INSTRUMENTS & INSTRUMENTATION
Chong Li, Balapuwaduge Lihini Mendis, Lisa Holland, Peng Li
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引用次数: 0

Abstract

Sharp edge structures have been demonstrated as an efficient way of generating acoustic streaming in microfluidic devices, which finds numerous applications in fluid mixing, pumping, particle actuation, and cell lysis. A sharp tip capillary is widely available means of generating sharp structures without the need of microfabrication, which has been used for studying enzyme kinetics, droplet digital PCR, and mass spectrometry analysis. In this work, we studied the influence of liquid inside the vibrating glass capillary on its efficiency of generating acoustic streaming. Using fluorescence microscopy and fluorescent particles, we observed that adding liquid to the inside of the vibrating glass capillary changed the streaming patterns as well as led to increased streaming velocity. Based on the observed streaming patterns, we hypothesized the liquid present in the capillary changed vibration mode of the capillary, which is matched with COMSOL simulations. Finally, the utility of the liquid filled vibrating capillary was demonstrated for higher energy efficiency for fluid mixing and mass spectrometry experiments. This study will provide useful guidance when optimizing the efficiency of vibrating sharp tip capillary systems.

研究液体存在对振动尖头毛细管产生的声流的影响
摘要 尖锐边缘结构已被证明是在微流体设备中产生声流的一种有效方法,在流体混合、泵送、粒子驱动和细胞裂解方面应用广泛。锐尖毛细管是一种无需微加工即可产生锐尖结构的广泛手段,已被用于研究酶动力学、液滴数字 PCR 和质谱分析。在这项工作中,我们研究了振动玻璃毛细管内部液体对其产生声流效率的影响。利用荧光显微镜和荧光颗粒,我们观察到在振动玻璃毛细管内部添加液体改变了流模式,并提高了流速度。根据观察到的流型,我们推测毛细管中的液体改变了毛细管的振动模式,这与 COMSOL 仿真结果相吻合。最后,我们证明了充满液体的振动毛细管在流体混合和质谱分析实验中具有更高的能效。这项研究将为优化振动尖头毛细管系统的效率提供有用的指导。
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来源期刊
Microfluidics and Nanofluidics
Microfluidics and Nanofluidics 工程技术-纳米科技
CiteScore
4.80
自引率
3.60%
发文量
97
审稿时长
2 months
期刊介绍: Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).
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