Plasma proteomic profile of abdominal obesity in older adults

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2024-03-04 DOI:10.1002/oby.24000

Sanish Sathyan, Sofiya Milman, Emmeline Ayers, Tina Gao, Joe Verghese, Nir Barzilai

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Abstract

Objective

This study examines the plasma proteomic profile of abdominal obesity in older adults.

Methods

The association of abdominal obesity (waist circumference [WC]) with 4265 plasma proteins identified using the SomaScan Assay was examined in 969 Ashkenazi Jewish participants (LonGenity cohort), aged 65 years and older (mean [SD] age 75.7 [6.7] years, 55.4% women), using regression models. Pathway analysis, as well as weighted correlation network analysis, was performed. WC was determined from the proteome using elastic net regression.

Results

A total of 480 out of 4265 proteins were associated with WC in the linear regression model. Leptin (β [SE] = 12.363 [0.490]), inhibin β C chain (INHBC; β [SE] = 24.324 [1.448]), insulin-like growth factor-binding protein 2 (IGFBP-2; β [SE] = −12.782 [0.841]), heparan-sulfate 6-O-sulfotransferase 3 (H6ST3; β [SE] = −39.995 [2.729]), and matrix-remodeling-associated protein 8 (MXRA8; β [SE] = −27.101 [1.850]) were the top proteins associated with WC. Cell adhesion, extracellular matrix remodeling, and IGF transport pathways were the top enriched pathways associated with WC. WC signature determined from plasma proteins was highly correlated with measured WC (r = 0.80) and was associated with various metabolic and physical traits.

Conclusions

The study unveiled a multifaceted plasma proteomic profile of abdominal obesity in older adults, offering insights into its wide-ranging impact on the proteome. It also elucidated novel proteins, clusters of correlated proteins, and pathways that are intricately associated with abdominal obesity.

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查看原文本刊更多论文

老年人腹部肥胖症的血浆蛋白质组概况。

研究目的本研究探讨了老年人腹部肥胖的血浆蛋白质组学特征：使用回归模型研究了 969 名年龄在 65 岁及以上（平均 [SD] 年龄为 75.7 [6.7]岁，55.4% 为女性）的阿什肯纳兹犹太参与者（LonGenity 队列）的腹部肥胖（腰围 [WC]）与 4265 种使用 SomaScan 分析法鉴定的血浆蛋白质之间的关系。进行了通路分析和加权相关网络分析。使用弹性网回归法从蛋白质组中确定 WC：结果：在线性回归模型中，4265 个蛋白质中共有 480 个与体重相关。瘦素（β [SE] = 12.363 [0.490]）、抑制素 β C 链（INHBC；β [SE] = 24.324 [1.448]）、胰岛素样生长因子结合蛋白 2（IGFBP-2；β [SE] = -12.782 [0.841]）、硫酸肝素-6-O-磺基转移酶 3（H6ST3；β[SE] = -39.995 [2.729]）和基质重塑相关蛋白 8（MXRA8；β[SE] = -27.101 [1.850]）是与 WC 相关的最主要蛋白质。细胞粘附、细胞外基质重塑和 IGF 转运途径是与 WC 相关的最重要的富集途径。根据血浆蛋白确定的 WC 特征与测量的 WC 高度相关（r = 0.80），并与各种代谢和体能特征相关：该研究揭示了老年人腹部肥胖的多方面血浆蛋白质组特征，为了解腹部肥胖对蛋白质组的广泛影响提供了见解。研究还阐明了与腹型肥胖密切相关的新型蛋白质、相关蛋白质群和通路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.

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