Nuclear imaging to visualize periodontal inflammation: Findings of a randomized controlled trial.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-03-04 DOI:10.1111/odi.14916

Behrouz Arefnia, Anja Horina, Tina Nazerani-Zemann, Gerald Seinost, Marcus Rieder, Gernot Wimmer

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引用次数: 0

Abstract

Objective: To investigate non-surgical periodontal therapy by 18F-fluorodeoxyglucose (2-[¹⁸F]FDG) uptake using positron emission tomography (PET) integrated with computed tomography (CT).

Subjects: Eighty-five patients with peripheral artery disease and severe periodontitis-randomized into three groups receiving therapy with (PT1; n = 29) or without (PT2; n = 28) systemic antibiotics or no treatment (controls: n = 28)-underwent nuclear imaging at baseline and at 3 months.

Results: Clinical inflammation (periodontal inflamed surface area; PISA) did not significantly differ across the groups at baseline (p = 0.395) but was significantly reduced at 3 months (p < 0.001), and significantly more so in the PT1/PT2 groups than in the control group (p < 0.001/=0.025) and in the PT1 than in the P2 group (p = 0.001). Radiotracer uptake was measured in both jaws using maximum and mean 'standardized uptake values' (SUV_max, SUV_mean) and 'target-to-background ratios' (TBR_max, TBR_mean). At 3 months, reductions were relatively small in absolute numbers and fell short of revealing correlations with PISA or significant differences across the groups. Still, they were very consistent in both treatment groups, whereas reductions were not consistently seen in the control group.

Conclusions: 2-[¹⁸F]FDG PET/CT scans did reflect the clinical effects of periodontal treatment very consistently but, for reasons yet to be clarified, less closely than expected.

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通过核成像观察牙周炎症：随机对照试验结果。

目的通过正电子发射断层扫描（PET）和计算机断层扫描（CT）相结合的方法，利用18F-氟脱氧葡萄糖（2-[18 F]FDG ）摄取量对非手术牙周治疗进行研究：85名患有外周动脉疾病和严重牙周炎的患者被随机分为三组，分别接受使用（PT1；n = 29）或不使用（PT2；n = 28）系统抗生素的治疗，或不接受治疗（对照组：n = 28）：结果：临床炎症（牙周炎症表面积；PISA）在基线时在各组间无显著差异（p = 0.395），但在 3 个月时显著降低（p 最大值、SUV 平均值）和 "目标-背景比率"（TBRmax、TBRmean）。3 个月时，降低的绝对数字相对较小，不足以显示与 PISA 的相关性或各组之间的显著差异。尽管如此，两个治疗组的降低幅度非常一致，而对照组的降低幅度并不一致：结论：2-[18 F]FDG PET/CT 扫描确实能非常一致地反映牙周治疗的临床效果，但由于原因尚待明确，其反映效果不如预期的那么密切。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.