Dietary habits and plasma lipid concentrations in a general Japanese population.

IF 3.5 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Metabolomics Pub Date : 2024-03-05 DOI:10.1007/s11306-024-02087-1

Mitsuharu Sato, Eiji Hishinuma, Naomi Matsukawa, Yoshiko Shima, Daisuke Saigusa, Ikuko N Motoike, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

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引用次数: 0

Abstract

Introduction: Accumulating data on the associations between food consumption and lipid composition in the body is essential for understanding the effects of dietary habits on health.

Objectives: As part of omics research in the Tohoku Medical Megabank Community-Based Cohort Study, this study sought to reveal the dietary impact on plasma lipid concentration in a Japanese population.

Methods: We conducted a correlation analysis of food consumption and plasma lipid concentrations measured using mass spectrometry, for 4032 participants in Miyagi Prefecture, Japan.

Results: Our analysis revealed 83 marked correlations between six food categories and the concentrations of plasma lipids in nine subclasses. Previously reported associations, including those between seafood consumption and omega-3 fatty acids, were validated, while those between dairy product consumption and odd-carbon-number fatty acids (odd-FAs) were validated for the first time in an Asian population. Further analysis suggested that dairy product consumption is associated with odd-FAs via sphingomyelin (SM), which suggests that SM is a carrier of odd-FAs. These results are important for understanding odd-FA metabolism with regards to dairy product consumption.

Conclusion: This study provides insight into the dietary impact on plasma lipid concentration in a Japanese population.

Abstract Image

查看原文本刊更多论文

日本普通人群的饮食习惯和血浆脂质浓度。

导言：要了解饮食习惯对健康的影响，就必须积累有关食物摄入量与体内脂质组成之间关系的数据：本研究是东北医学大型数据库社区队列研究中的一项omics研究，旨在揭示饮食对日本人群血浆脂质浓度的影响：方法：我们对日本宫城县 4032 名参与者的食物摄入量和使用质谱仪测量的血浆脂质浓度进行了相关性分析：结果：我们的分析发现，六类食物与九个亚类的血浆脂质浓度之间存在 83 种明显的相关性。之前报道的相关性，包括海产品消费与欧米加-3 脂肪酸之间的相关性得到了验证，而乳制品消费与奇数碳脂肪酸（odd-FAs）之间的相关性则首次在亚洲人群中得到了验证。进一步的分析表明，乳制品消费通过鞘磷脂（SM）与奇数脂肪酸相关，这表明鞘磷脂是奇数脂肪酸的载体。这些结果对于了解与乳制品消费有关的奇异羧酸代谢非常重要：本研究有助于深入了解膳食对日本人群血浆脂质浓度的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolomics 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.80%

发文量

审稿时长

2 months

期刊介绍： Metabolomics publishes current research regarding the development of technology platforms for metabolomics. This includes, but is not limited to: metabolomic applications within man, including pre-clinical and clinical pharmacometabolomics for precision medicine metabolic profiling and fingerprinting metabolite target analysis metabolomic applications within animals, plants and microbes transcriptomics and proteomics in systems biology Metabolomics is an indispensable platform for researchers using new post-genomics approaches, to discover networks and interactions between metabolites, pharmaceuticals, SNPs, proteins and more. Its articles go beyond the genome and metabolome, by including original clinical study material together with big data from new emerging technologies.