Salivary and serum biomarkers to evaluate psychological disorders in burning mouth syndrome: A systematic review and meta-analysis

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-03-04 DOI:10.1111/jop.13526

Mei He, Wuda Huoshen, Xueqing Li, Chen Sun

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Abstract

Background

Burning mouth syndrome is a chronic pain syndrome mainly characterized by an intensive burning sensation of tongue. Previous studies have suggested that saliva/serum biomarkers in burning mouth syndrome might be associated with psychological disorders. The aim of systematic review was to observe whether the biomarkers in serum/saliva could be an alternative method to evaluate the psychological disorders in patients with burning mouth syndrome.

Materials and Methods

The PubMed, Embase, and Cochrane Library databases were searched for papers published up to March 15, 2023. Risk of bias was measured by using the Newcastle-Ottawa Scale. RevMan was used for meta-analysis.

Results

A total of 467 articles were screened, which of 12 studies were included. These studies collected 43 different biomarkers in saliva and 35 in serum. Of these biomarkers, only three (cortisol, α-amylase, and IL-6) were analyzed in two or more studies. Only salivary cortisol levels were significantly higher in the patient group compared to the controls (Mean Difference = 1.39; 95% CI [0.80–1.97]; p < 0.001). Moreover, cortisol might be relevant to psychological scores, especially anxiety.

Conclusion

Different papers have investigated salivary and serum biomarkers in burning mouth syndrome patients with controversial results. This meta-analysis showed that cortisol levels in saliva may be a potential biomarker to assess the psychological disorders in burning mouth syndrome patients.

查看原文本刊更多论文

评估灼口综合征心理障碍的唾液和血清生物标记物：系统回顾和荟萃分析。

背景介绍灼口综合征是一种慢性疼痛综合征，主要特征是舌头有强烈的灼烧感。以往的研究表明，烧灼感口腔综合征的唾液/血清生物标志物可能与心理障碍有关。系统综述的目的是观察血清/唾液中的生物标志物是否可以作为评估灼口综合征患者心理障碍的替代方法：在PubMed、Embase和Cochrane图书馆数据库中检索了截至2023年3月15日发表的论文。使用纽卡斯尔-渥太华量表测量偏倚风险。RevMan用于荟萃分析：共筛选出 467 篇文章，其中 12 项研究被纳入。这些研究在唾液中收集了 43 种不同的生物标记物，在血清中收集了 35 种不同的生物标记物。在这些生物标志物中，只有三种（皮质醇、α-淀粉酶和 IL-6）在两项或两项以上的研究中进行了分析。只有患者组的唾液皮质醇水平明显高于对照组（平均差 = 1.39；95% CI [0.80-1.97]；P 结论：患者组的唾液皮质醇水平明显高于对照组（平均差 = 1.39；95% CI [0.80-1.97]）：不同的论文对烧灼伤口腔综合征患者的唾液和血清生物标志物进行了研究，但结果存在争议。这项荟萃分析表明，唾液中的皮质醇水平可能是评估灼口综合征患者心理障碍的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464