The gut microbiome modulates the susceptibility to traumatic stress in a sex-dependent manner

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Dan Shen, Liang Chang, Feng Su, Shihao Huang, Hubo Xu, Yue Si, Feng Wang, Yanxue Xue
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Abstract

Post-traumatic stress disorder (PTSD), a psychological condition triggered by exposure to extreme or chronic stressful events, exhibits a sex bias in incidence and clinical manifestations. Emerging research implicates the gut microbiome in the pathogenesis of PTSD and its roles in stress susceptibility. However, it is unclear whether differential gut microbiota contribute to PTSD susceptibility in male and female rats. Here, we utilized the single prolonged stress animal model and employed unsupervised machine learning to classify stressed animals into stress-susceptible subgroups and stress-resilient subgroups. Subsequently, using 16S V3-V4 rDNA sequencing, we investigated the differential gut microbiota alterations between susceptible and resilient individuals in male and female rats. Our findings revealed distinct changes in gut microbiota composition between the sexes at different taxonomic levels. Furthermore, the abundance of Parabacteroides was lower in rats that underwent SPS modeling compared to the control group. In addition, the abundance of Tenericutes in the stress-susceptible subgroup was higher than that in the control group and stress-resilient subgroup, suggesting that Tenericutes may be able to characterize stress susceptibility. What is particularly interesting here is that Cyanobacteria may be particularly associated with anti-anxiety effects in male rats. This study underscores sex-specific variations in gut microbiota composition in response to stress and sex differences should be taken into account when using macrobiotics for neuropsychiatric treatment, highlighting potential targets for PTSD therapeutic interventions.

肠道微生物组以性别依赖的方式调节创伤应激的易感性。
创伤后应激障碍(PTSD)是一种因遭受极端或慢性应激事件而引发的心理疾病,在发病率和临床表现上都存在性别差异。新近的研究表明,肠道微生物组与创伤后应激障碍的发病机制及其在应激易感性中的作用有关。然而,目前还不清楚不同的肠道微生物群是否会导致雄性和雌性大鼠对创伤后应激障碍的易感性。在这里,我们利用单次长期应激动物模型,并采用无监督机器学习将应激动物分为应激易感亚组和应激抗性亚组。随后,我们利用 16S V3-V4 rDNA 测序技术研究了雌雄大鼠中易受应激影响个体和抗应激个体之间肠道微生物群的不同变化。我们的研究结果表明,在不同的分类水平上,雌雄大鼠的肠道微生物群组成发生了明显的变化。此外,与对照组相比,接受 SPS 模型的大鼠中 Parabacteroides 的丰度较低。此外,应激易感亚组中的Tenericutes丰度高于对照组和应激抗性亚组,这表明Tenericutes可能能够描述应激易感性。特别有趣的是,蓝藻可能与雄性大鼠的抗焦虑作用特别相关。这项研究强调了肠道微生物群组成在应激反应中的性别差异,在使用大生物疗法治疗神经精神疾病时应考虑到性别差异,并突出了创伤后应激障碍治疗干预的潜在目标。
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来源期刊
Journal of Neuroscience Research
Journal of Neuroscience Research 医学-神经科学
CiteScore
9.50
自引率
2.40%
发文量
145
审稿时长
1 months
期刊介绍: The Journal of Neuroscience Research (JNR) publishes novel research results that will advance our understanding of the development, function and pathophysiology of the nervous system, using molecular, cellular, systems, and translational approaches. JNR covers both basic research and clinical aspects of neurology, neuropathology, psychiatry or psychology. The journal focuses on uncovering the intricacies of brain structure and function. Research published in JNR covers all species from invertebrates to humans, and the reports inform the readers about the function and organization of the nervous system, with emphasis on how disease modifies the function and organization.
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