Wenjie Tang, Yusen Wei, Zhixiang Ni, Kangwei Hou, Xin M Luo, Haifeng Wang
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引用次数: 0
Abstract
The mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that CD138+ plasmacyte (PC)-mediated promotion of IgA response regulates the symbiosis between Bacteroides uniformis (B. uniformis) and the host during the weaning period. The IgA-skewed response of CD138+ PCs is essential for B. uniformis to occupy a defined gut luminal niche, thereby fostering stable colonization. Furthermore, B. uniformis within the natural gut niche was perturbed in the absence of IgA, resulting in exacerbated gut inflammation in IgA-deficient mice and weaned piglets. Thus, we propose that the priming and maintenance of intestinal IgA response from CD138+ PCs are required for host-microbial symbiosis, whereas the perturbation of which would enhance inflammation in weaning process.
在断奶时，宿主与微生物之间的共生关系是如何在B细胞监控下建立起来的，其机制仍未得到充分阐明。我们发现，CD138+质粒（PC）介导的 IgA 反应促进调节了断奶期均匀乳杆菌（B. uniformis）与宿主之间的共生关系。CD138+ PC 的 IgA 偏斜反应对于制服乳杆菌占据确定的肠腔生态位从而促进稳定定殖至关重要。此外，在缺乏 IgA 的情况下，B. uniformis 在自然肠道壁龛内的活动受到干扰，导致 IgA 缺乏的小鼠和断奶仔猪的肠道炎症加剧。因此，我们认为 CD138+ PCs 启动和维持肠道 IgA 反应是宿主-微生物共生所必需的，而干扰这种共生会加剧断奶过程中的炎症。
期刊介绍：
The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more.
Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.
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