Liposomes: An Emerging Strategy for the Effective Treatment of Rheumatoid Arthritis.

IF 1.2 Q4 RHEUMATOLOGY
Vani, Priyanka Kriplani, Ashwani Dhingra, Bhawna Chopra, Ajmer Singh Grewal, Geeta Deswal, Rameshwar Dass, Kumar Guarve
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引用次数: 0

Abstract

Background: A Liposomal delivery system is a novel and distinguishing way of organized medicine administration. The advancements in liposomal technology allow for controlled drug distribution to treat rheumatoid arthritis effectively. Liposomes are microscopic lipid-based vesicles that have shown promise in transporting substances, such as superoxide dismutase, hemoglobin, erythrocyte interleukin-2, gamma interferon, and smaller compounds.

Objective: Liposomes are biocompatible, nontoxic, biodegradable, non-immunogenic, and flexible, with sizes ranging from 0.025 to 2.5 micrometers. LDS is normally employed to distribute drugs through topical conduits, but fresh investigation has shown that it offers promise for oral, ocular, and parenteral administration. Our major objective is to gather information about liposomes, focusing on their applicability in rheumatoid arthritis treatment.

Methods: In the current review, we have tried to cover the preparation techniques, clinical trials, patents, marketed formulations, vesicle types, formulations used to treat rheumatoid arthritis and other ailments, and layered liposomal formulations with improved characteristics.

Conclusion: Research has established LDS as a biocompatible, sustainable, non-toxic, adaptable material. Researchers working on LDS technology in rheumatoid arthritis will find this review particularly useful as it may unclutter novel ways for therapeutic intercessions in treating the disease.

脂质体:有效治疗类风湿性关节炎的新策略。
背景:脂质体给药系统是一种新颖独特的组织给药方式。脂质体技术的进步可以控制药物分布,从而有效治疗类风湿性关节炎。脂质体是以脂质为基础的微小囊泡,在运输物质(如超氧化物歧化酶、血红蛋白、红细胞白细胞介素-2、γ 干扰素和更小的化合物)方面显示出良好的前景:脂质体具有生物相容性、无毒、可生物降解、无免疫原性和柔韧性,大小从 0.025 微米到 2.5 微米不等。LDS 通常用于通过局部导管分配药物,但最新研究表明,它有望用于口服、眼部和肠外给药。我们的主要目的是收集有关脂质体的信息,重点关注其在类风湿性关节炎治疗中的适用性:在本综述中,我们试图涵盖制备技术、临床试验、专利、上市制剂、囊泡类型、用于治疗类风湿性关节炎和其他疾病的制剂,以及具有改良特性的分层脂质体制剂:研究表明,LDS 是一种生物兼容、可持续、无毒、适应性强的材料。研究类风湿性关节炎的 LDS 技术的研究人员会发现这篇综述特别有用,因为它可能会为治疗类风湿性关节炎的新疗法提供新的思路。
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来源期刊
CiteScore
2.30
自引率
0.00%
发文量
82
期刊介绍: Current Rheumatology Reviews publishes frontier reviews on all the latest advances on rheumatology and its related areas e.g. pharmacology, pathogenesis, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in rheumatology.
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