Impact of respiratory viral infections on nasopharyngeal pneumococcal colonization dynamics in children.

IF 3.6 3区 医学 Q2 INFECTIOUS DISEASES
Current Opinion in Infectious Diseases Pub Date : 2024-06-01 Epub Date: 2024-03-04 DOI:10.1097/QCO.0000000000001008
Leigh M Howard, Carlos G Grijalva
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引用次数: 0

Abstract

Purpose of review: Prevention of acute respiratory illnesses (ARI) in children is a global health priority, as these remain a leading cause of pediatric morbidity and mortality throughout the world. As new products and strategies to prevent respiratory infections caused by important pathogens such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza, respiratory syncytial virus and pneumococcus are advancing, increasing evidence suggests that these and other respiratory viruses and pneumococci may exhibit interactions that are associated with altered colonization and disease dynamics. We aim to review recent data evaluating interactions between respiratory viruses and pneumococci in the upper respiratory tract and their potential impact on pneumococcal colonization patterns and disease outcomes.

Recent findings: While interactions between influenza infection and subsequent increased susceptibility and transmissibility of colonizing pneumococci have been widely reported in the literature, emerging evidence suggests that human rhinovirus, SARS-CoV-2, and other viruses may also exhibit interactions with pneumococci and alter pneumococcal colonization patterns. Additionally, colonizing pneumococci may play a role in modifying outcomes associated with respiratory viral infections. Recent evidence suggests that vaccination with pneumococcal conjugate vaccines, and prevention of colonization with pneumococcal serotypes included in these vaccines, may be associated with reducing the risk of subsequent viral infection and the severity of the associated illnesses.

Summary: Understanding the direction and dynamics of viral-pneumococcal interactions may elucidate the potential effects of existing and emerging viral and bacterial vaccines and other preventive strategies on the health impact of these important respiratory pathogens.

呼吸道病毒感染对儿童鼻咽肺炎球菌定植动态的影响。
审查目的:预防儿童急性呼吸道疾病(ARI)是全球健康的当务之急,因为这些疾病仍然是全世界儿科发病率和死亡率的主要原因。随着预防严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)、流感、呼吸道合胞病毒和肺炎球菌等重要病原体引起的呼吸道感染的新产品和新策略不断推陈出新,越来越多的证据表明,这些和其他呼吸道病毒与肺炎球菌之间可能存在相互作用,而这种相互作用与定植和疾病动态的改变有关。我们旨在回顾最近的数据,评估呼吸道病毒和肺炎球菌在上呼吸道中的相互作用及其对肺炎球菌定植模式和疾病结果的潜在影响:虽然文献中广泛报道了流感感染与定植肺炎球菌的易感性和传播性增加之间的相互作用,但新出现的证据表明,人类鼻病毒、SARS-CoV-2 和其他病毒也可能与肺炎球菌发生相互作用,并改变肺炎球菌的定植模式。此外,定植的肺炎球菌还可能在改变与呼吸道病毒感染相关的结果方面发挥作用。最近的证据表明,接种肺炎球菌结合疫苗和预防这些疫苗所含肺炎球菌血清型的定植可能与降低后续病毒感染的风险和相关疾病的严重程度有关。摘要:了解病毒与肺炎球菌相互作用的方向和动态可阐明现有和新出现的病毒和细菌疫苗及其他预防策略对这些重要呼吸道病原体的健康影响的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.70
自引率
2.60%
发文量
121
审稿时长
6-12 weeks
期刊介绍: This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.
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