Growth Signaling Networks Orchestrate Cancer Metabolic Networks

IF 7.8 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Brendan D. Manning, Christian C. Dibble
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引用次数: 0

Abstract

Normal cells grow and divide only when instructed to by signaling pathways stimulated by exogenous growth factors. A nearly ubiquitous feature of cancer cells is their capacity to grow independent of such signals, in an uncontrolled, cell-intrinsic manner. This property arises due to the frequent oncogenic activation of core growth factor signaling pathway components, including receptor tyrosine kinases, PI3K-AKT, RAS-RAF, mTORC1, and MYC, leading to the aberrant propagation of pro-growth signals independent of exogenous growth factors. The growth of both normal and cancer cells requires the acquisition of nutrients and their anabolic conversion to the primary macromolecules underlying biomass production (protein, nucleic acids, and lipids). The core growth factor signaling pathways exert tight regulation of these metabolic processes and the oncogenic activation of these pathways drive the key metabolic properties of cancer cells and tumors. Here, we review the molecular mechanisms through which these growth signaling pathways control and coordinate cancer metabolism.
生长信号网络协调癌症代谢网络
正常细胞只有在外源性生长因子刺激的信号通路指示下才会生长和分裂。癌细胞的一个几乎无处不在的特征是,它们能够不受这些信号的影响,以不受控制的细胞内在方式生长。这一特性的产生是由于生长因子信号通路的核心成分(包括受体酪氨酸激酶、PI3K-AKT、RAS-RAF、mTORC1 和 MYC)经常被致癌物质激活,从而导致生长促进信号的异常传播,而不受外源性生长因子的影响。正常细胞和癌细胞的生长都需要获取营养物质,并将其合成代谢转化为产生生物量的基本大分子(蛋白质、核酸和脂质)。核心生长因子信号通路对这些代谢过程进行严格调控,而这些通路的致癌活化则驱动着癌细胞和肿瘤的关键代谢特性。在此,我们将回顾这些生长信号通路控制和协调癌症代谢的分子机制。
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来源期刊
Cold Spring Harbor perspectives in medicine
Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
14.30
自引率
1.90%
发文量
44
审稿时长
4-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.
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