Endothelial lipid droplets drive atherosclerosis and arterial hypertension.

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2024-06-01 Epub Date: 2024-03-01 DOI:10.1016/j.tem.2024.02.014

Suowen Xu, Stefan Offermanns

引用次数: 0

Abstract

Lipid droplets (LDs) are essential for cellular pathophysiology. In two recent reports, Kim et al. and Boutagy et al. show that accumulation of LDs in endothelial cells (ECs) elevates blood pressure and accelerates progression of atherosclerosis. These findings identify a novel mechanism of EC lipid metabolism which drives cardiometabolic diseases.

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内皮脂滴驱动动脉粥样硬化和动脉高血压。

脂滴（LDs）对细胞病理生理学至关重要。在最近的两篇报告中，Kim 等人和 Boutagy 等人发现，内皮细胞（EC）中积累的脂滴会升高血压并加速动脉粥样硬化的发展。这些研究发现了一种新的内皮细胞脂质代谢机制，它是心脏代谢疾病的诱因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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