Impaired Sleep in Patients with Post-COVID-19 Syndrome Compared to Healthy Controls: A Cross-Sectional Trial.

IF 3.5 3区医学 Q2 RESPIRATORY SYSTEM

Respiration Pub Date : 2024-01-01 Epub Date: 2024-03-01 DOI:10.1159/000536272

Inga Jarosch, Tessa Schneeberger, Antje Stegemann, Rainer Gloeckl, Daniela Leitl, Clancy Dennis, Wolfgang Hitzl, Christopher Schoen, Andreas Rembert Koczulla

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引用次数: 0

Abstract

Introduction: To objectify self-reported sleep disorders in individuals with post-COVID-syndrome (PCS), we aimed to investigate the prevalence and nature of sleep disturbances by polysomnography (PSG) in PCS compared to healthy individuals.

Methods: People with PCS (n = 21) and healthy controls (CON, n = 10) were included in this prospective trial. At baseline, clinical and social anamnesis, lung function, 1 min sit-to-stand test (STST) and Pittsburgh Sleep Quality Index (PSQI) were assessed. For a single-night, sleep health was evaluated by video-PSG. The apnoea/hypopnea index (AHI) was used as the primary outcome.

Results: Twenty patients with PCS (50 ± 11 y, BMI 27.1 m2/kg, SARS-CoV-2 infection 8.5 ± 4.5 months ago) and 10 CON participants (46 ± 10 y, BMI 23.0 m2/kg, no SARS-CoV-2 infection in the history) completed the study. Forced vital capacity (p = 0.018), STST repetitions (p < 0.001), and symptoms of dyspnoea (at rest: p = 0.002, exertion: p < 0.001) were worse in PCS compared to CON. PSQI score (PCS: 7.5 ± 4.7 points) was higher in PCS compared to CON (Δ = 3.7 points, 95% CI [0.4-7.1] p = 0.015), indicating poor sleep in 80% of patients with PCS. Although PSG showed comparable sleep stage distributions in both groups, AHI (Δ = 9.0 n/h, 95% CI [3.3-14.8], p = 0.002), PLM index (Δ = 5.1 n/h, 95% CI [0.4-9.8], p = 0.017), and the prevalence of sleep apnoea (60% vs. 10%, p = 0.028) was significantly higher in PCS compared to CON.

Conclusion: Quantifiable subjective limitations of sleep have been revealed by PSG data in this PCS cohort. More than half of PCS patients had signs of sleep apnoea, highlighting the importance of sleep screening in PCS.

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与健康对照组相比，COVID-19 后综合征患者睡眠受损：一项横断面试验

导言：为了客观了解后 COVID 综合征（PCS）患者自我报告的睡眠障碍情况，我们旨在通过多导睡眠图（PSG）调查 PCS 患者与健康人相比睡眠障碍的发生率和性质：这项前瞻性试验纳入了 PCS 患者（21 人）和健康对照组（10 人）。基线评估包括临床和社会病史、肺功能、1 分钟坐立测试（STST）和匹兹堡睡眠质量指数（PSQI）。通过视频 PSG 对单晚睡眠健康状况进行评估。以呼吸暂停/低通气指数（AHI）作为主要结果：20 名 PCS 患者（50 ± 11 岁，体重指数 27.1 m2/kg，8.5 ± 4.5 个月前感染过 SARS-CoV-2）和 10 名 CON 参与者（46 ± 10 岁，体重指数 23.0 m2/kg，无 SARS-CoV-2 感染史）完成了研究。与CON相比，PCS患者的用力肺活量（p = 0.018）、STST重复次数（p < 0.001）和呼吸困难症状（休息时：p = 0.002，用力时：p < 0.001）均较差。PCS患者的PSQI评分（PCS：7.5 ± 4.7分）高于CON患者（Δ = 3.7分，95% CI [0.4-7.1] p = 0.015），表明80%的PCS患者睡眠质量差。虽然 PSG 显示两组患者的睡眠阶段分布相当，但与 CON 相比，PCS 患者的 AHI（Δ = 9.0 n/h，95% CI [3.3-14.8]，p = 0.002）、PLM 指数（Δ = 5.1 n/h，95% CI [0.4-9.8]，p = 0.017）和睡眠呼吸暂停发生率（60% vs. 10%，p = 0.028）明显更高：结论：PCS 队列中的 PSG 数据揭示了可量化的主观睡眠限制。半数以上的 PCS 患者有睡眠呼吸暂停的迹象，这凸显了对 PCS 进行睡眠筛查的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiration 医学-呼吸系统

CiteScore

7.30

自引率

5.40%

发文量

审稿时长

4-8 weeks

期刊介绍： ''Respiration'' brings together the results of both clinical and experimental investigations on all aspects of the respiratory system in health and disease. Clinical improvements in the diagnosis and treatment of chest and lung diseases are covered, as are the latest findings in physiology, biochemistry, pathology, immunology and pharmacology. The journal includes classic features such as editorials that accompany original articles in clinical and basic science research, reviews and letters to the editor. Further sections are: Technical Notes, The Eye Catcher, What’s Your Diagnosis?, The Opinion Corner, New Drugs in Respiratory Medicine, New Insights from Clinical Practice and Guidelines. ''Respiration'' is the official journal of the Swiss Society for Pneumology (SGP) and also home to the European Association for Bronchology and Interventional Pulmonology (EABIP), which occupies a dedicated section on Interventional Pulmonology in the journal. This modern mix of different features and a stringent peer-review process by a dedicated editorial board make ''Respiration'' a complete guide to progress in thoracic medicine.