Admission proteinuria predicts the incidence of acute kidney injury among patients with acute ST-segment elevation myocardial infarction: a retrospective cohort study.
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引用次数: 0
Abstract
Background: Proteinuria indicates renal dysfunction and is associated with the development of acute kidney injury (AKI) in several conditions, but the association between proteinuria and AKI in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. This research aims to investigate the predictive value of proteinuria for the development of AKI in STEMI patients.
Methods: A total of 2735 STEMI patients were enrolled. The present study's endpoint was AKI incidence during hospitalization. AKI is defined according to the Kidney Disease: Improving Global Outcomes criteria. We defined proteinuria, measured with a dipstick, as mild (1+) or heavy (2+ to 4+). Multivariate logistic regression and subgroup analyses were used to testify to the association between proteinuria and AKI.
Results: Overall, proteinuria was observed in 634 (23.2%) patients. Multivariate logistic regression analyses revealed that proteinuria [odds ratio (OR), 1.58; 95% confidence interval (CI), 1.25-2.00; P < 0.001] was the independent predictive factor for AKI. Severe proteinuria was associated with a higher adjusted risk for AKI compared with the nonproteinuria group (mild proteinuria: OR, 1.35; 95% CI, 1.04-1.75; P = 0.025; severe proteinuria: OR, 2.50; 95% CI, 1.70-3.68; P < 0.001). The association was highly consistent across all studied subgroups. (all P for interaction >0.05).
Conclusion: Admission proteinuria measured using a urine dipstick is an independent risk factor for the development of AKI in STEMI patients.
背景：蛋白尿提示肾功能障碍，在多种情况下与急性肾损伤（AKI）的发生有关，但蛋白尿与ST段抬高型心肌梗死（STEMI）患者AKI之间的关系仍不清楚。本研究旨在探讨蛋白尿对 STEMI 患者发生 AKI 的预测价值：方法：共招募了 2735 名 STEMI 患者。本研究的终点是住院期间的 AKI 发生率。AKI 根据肾脏疾病：改善全球预后标准》对 AKI 进行了定义。我们将用量尺测量的蛋白尿定义为轻度（1+）或重度（2+至4+）。多变量逻辑回归和亚组分析用于证实蛋白尿与 AKI 之间的关联：结果：总计有 634 名（23.2%）患者出现蛋白尿。多变量逻辑回归分析显示，蛋白尿[几率比（OR），1.58；95% 置信区间（CI），1.25-2.00；P 0.05]：结论：使用尿液量尺测量入院时的蛋白尿是 STEMI 患者发生 AKI 的独立风险因素。
期刊介绍：
Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management.
Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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